Radiomics model-based algorithm for preoperative prediction of pancreatic ductal adenocarcinoma grade.

Objective: To develop diagnostic radiomic model-based algorithm for pancreatic ductal adenocarcinoma (PDAC) grade prediction.

Methods: Ninety-one patients with histologically confirmed PDAC and preoperative CT were divided into subgroups based on tumor grade. Two histology-blinded radiologists independently segmented lesions for quantitative texture analysis in all contrast enhancement phases.

Computed tomography-based radiomics approach in pancreatic tumors characterization.

Radiomics (or texture analysis) is a new imaging analysis technique that allows calculating the distribution of texture features of pixel and voxel values depend on the type of ROI (3D or 2D), their relationships in the image. Depending on the software, up to several thousand texture elements can be obtained. Radiomics opens up wide opportunities for differential diagnosis and prognosis of pancreatic neoplasias.

Reproducibility of CT texture features of pancreatic neuroendocrine neoplasms.

Purpose: To evaluate the reproducibility of textural features of pancreatic neuroendocrine neoplasms (PNENs), obtained under various CT-scanning conditions.

Methods And Materials: We included 12 patients with PNENs and 2 contrast enhanced CT (CECT): 1) from our center according to standard CT-protocol; 2) from another institution. Two radiologists independently segmented the entire neoplasm volume using a 3D region of interest by LIFEx application on the arterial phase and then copied it to the other phases.

[Use of fludarabin in conjunction with other cytostatics in the treatment of non-Hodgkin lymphoma resistant to standard chemotherapy].

The investigation involved 50 patients (fludarabin+cyclophosphamide+prednisolone (FCP)--30; fludarabin+mitoxanthrone+prednisolone (FMP)--17; fludarabin+cyclophosphamide--3). FMP proved the most effective (60%). Yet, FCP results were clinically significant (29%).

[Clinical trial of the monoclonal antibody drug mabthera (Rituximab) in the treatment of non-Hodgkin lymphoma].

Mabthera has been tested for its influence on relapsing and refractory low-grade non-Hodgkin's lymphoma in a comparative study using monotherapy (R) or in conjunction with CHOP (R-CHOP) chemotherapy. Out of 33 in-patients, effect was evaluated in 31 (rituximab monotherapy--16, R-CHOP--31). MabThera monochemotherapy proved effective in 62% of those who had received several other regimes, R-CHOP-74%.

[Use of quantitative histochemistry in the prognosis of renal cell cancer].

The study was concerned with evaluating the quantitative histochemical and histoenzymatic peculiarities of renal cell carcinoma of various grade of malignancy. It involved measuring levels of lipids, glycogen, protein, nucleic acids and sugar as well as the activities of dehydrogenases, phosphatases, non-specific esterase and lipase in tumor cells. Grade I neoplasms were found to be associated with low proliferative activity matched by relatively high energy production thus causing excessive synthesis of lipids and glycogen to occur.

[The degree of malignancy and histologic variants of kidney cancer: their importance in diagnosis and prognosis].

Basing on quantitative morphological and histochemical findings, 170 cases of renal carcinoma were divided into 3 (I, II, III) grades of malignancy. This grading system is of a high prognostic significance. Histological variant, i.