Publications by authors named "Tikeng Jiang"
Article Synopsis
- Aflatoxin B1 (AFB1) is a harmful compound that can cause cancer and is activated in the body by specific enzymes called cytochrome P450 (CYP) 1A2 and 3A4; previous research suggested it caused genetic damage in engineered yeast cells expressing CYP1B1.
- This study engineered human liver (L-02) and lymphocyte (TK6) cell lines to express CYP1B1, exposing them to AFB1 and observing effects such as increased DNA damage and genetic changes compared to unmodified cells, indicating a heightened response due to CYP1B1 presence.
- Results showed that CYP1B1 not only
Reprogramming of cellular metabolism is a vital event during tumorigenesis. The role of glycolysis in malignant progression promoted by hydroquinone (HQ), one of the metabolic products of benzene, remains to be understood. Recently, we reported the overexpression of sirtuin 1 (SIRT1) in HQ-enhanced malignant progression of TK6 cells and hypothesized that SIRT1 might contribute to glycolysis and favor tumorigenesis.
View Article and Find Full Text PDFBackground: The coiled-coil domain containing (CCDC) family proteins have important biological functions in various diseases. However, the coiled-coil domain containing 137 (CCDC137) was rarely studied. We aim to investigate the role of CCDC137 in pan-cancer.
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