New horizons for magic-angle spinning NMR.

Recent developments in sample rotation technology have had a profound impact on magic-angle-spinning NMR. First, rotation frequencies approaching, and even exceeding, strong homonuclear spin interactions have made high-resolution solid-state (1)H spectroscopy much more accessible. Second, the new concept of fast rotation sweep spectroscopy has emerged.

Low-power high-resolution solid-state NMR of peptides and proteins.

We demonstrate that two-dimensional solid-state NMR chemical-shift correlation spectra can be recorded under low-power conditions. Except for the cross-polarization period, no rf-field amplitudes above 40 kHz are used. Such experiments require the use of fast (>50 kHz) magic-angle spinning (MAS).