Publications by authors named "Tiing-Tiing Chua"
Article Synopsis
- In Southeast Asia and northern Australia, infections are common but often misdiagnosed, leading to high mortality rates of up to 50%.
- A 2018 pilot study involved 100 patients with infection symptoms at Kapit Hospital in Malaysia, using three diagnostic methods—including PCR and rapid testing—to detect infections.
- The study found that while the individual diagnostic tests had low sensitivity (25-44%) compared to the gold standard of bacterial culture, they demonstrated high specificity (93-98%), indicating a need for more sensitive diagnostics for better disease detection.
Tissue culture medium routinely contains fetal bovine serum (FBS). Here we show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells. When moved to HS, these cells show differential transcription of 22-32% of the genes, stop proliferating, and assume a hepatocyte-like morphology.
View Article and Find Full Text PDFMetal homeostasis is a crucial cellular function for nearly all organisms. Some heavy metals (e.g.
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