Publications by authors named "Tiina J Ahonen"
Article Synopsis
- 12-Thiazole abietanes are special compounds that can help stop a brain problem called neuroinflammation by blocking a specific enzyme named hABHD16A.
- Scientists used different techniques to understand which parts of these compounds make them work better against hABHD16A while not affecting another enzyme, hABHD12.
- One compound showed to be super effective at blocking hABHD16A, but if it had a certain structure, it could accidentally block hABHD12 instead, which means the design of these compounds is really important for making new medicines.
Article Synopsis
- TRPA1 is a cation channel linked to pain sensing and inflammation, primarily found in certain pain receptors.
- Researchers modified betulin to create 13 new triterpenoids and tested their ability to inhibit TRPA1, with 6 showing significant effects.
- Two triterpenoids (compounds 8 and 9) effectively blocked TRPA1 in lab tests and reduced inflammation in mice, suggesting potential for treating inflammation-related diseases.
Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiazole derivative , with an IC value of 3.4 ± 0.
View Article and Find Full Text PDFDespite extensive years of research, the direct oxidation of the 7,8-double bond of opioids has so far received little attention and knowledge about the effects of this modification on activity at the different opioid receptors is scarce. We herein report that potassium permanganate supported on iron(II) sulfate heptahydrate can be used as a convenient oxidant in the one-step, heterogeneous conversion of Δ-opioids to the corresponding 7β-hydroxy-8-ketones. Details of the reaction mechanism are given and the effects of the substituent at position 6 of several opioids on the reaction outcome is discussed.
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