Publications by authors named "Tihui Liu"
Hypoxia inhibits HUNK kinase activity to induce epithelial-mesenchymal transition.
Biochem Biophys Res Commun
November 2023
Hypoxia is a common hallmark of cancer and plays a crucial role in promoting epithelial-mesenchymal transition (EMT). Hormonally Upregulated Neu-associated Kinase (HUNK) regulates EMT through its kinase activity. However, whether hypoxia is involved in HUNK-mediated EMT is incompletely understood.
View Article and Find Full Text PDFEpitranscriptic regulation of by -methyladenosine drives tumor progression.
Proc Natl Acad Sci U S A
April 2023
Article Synopsis
- Overexpression of Ras, along with oncogenic mutations, is common in various human cancers, but the role of epitranscriptic regulation in this process is not well understood.
- * The study finds that higher levels of the -methyladenosine (mA) modification in cancer tissues lead to increased H-Ras protein expression, promoting cancer cell growth and spread.
- * Mechanistically, specific mA modification sites in the 3' UTR of H-Ras are regulated by the FTO gene and YTHDF1 protein, enhancing translation, and targeting this mA modification may decrease cancer progression.