The Cell Wall Deacetylases Spy1094 and Spy1370 Contribute to Virulence.

, or Group A Streptococcus (GAS), is a strictly human pathogen that causes a wide range of diseases, including skin and soft tissue infections, toxic shock syndrome and acute rheumatic fever. We have recently reported that Spy1094 and Spy1370 of serotype M1 are N-acetylglucosamine (GlcNAc) deacetylases. We have generated and gene deletion mutants in and gain-of-function mutants in .