Publications by authors named "Tiffany Yan"
Article Synopsis
- The study investigates the role of CD38 and NAD in reducing inflammation related to gout, particularly through the examination of macrophages and their response to monosodium urate (MSU) crystals.
- Researchers found that MSU crystals increase CD38 activity, leading to NAD depletion and the release of pro-inflammatory cytokines like IL-1β.
- Pharmacological inhibitors of CD38 as well as genetic knockout of CD38 demonstrated potential to reduce inflammation and modulate genes associated with an inflammatory response, suggesting that targeting CD38 and NAD could be a new approach to treating gouty arthritis.
SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced by authorized vaccines wanes within 6 months, and frequent boosts may only offer transient protection. GRT-R910 is an investigational self-amplifying mRNA (samRNA)-based SARS-CoV-2 vaccine delivering full-length Spike and selected conserved non-Spike T cell epitopes.
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