International validation of Enhanced Recovery After Surgery Society guidelines on enhanced recovery for gynecologic surgery.

Background: Enhanced Recovery After Surgery Society publishes guidelines on perioperative care, but these guidelines should be validated prospectively.

Objective: To evaluate the association between compliance with Enhanced Recovery After Surgery Gynecologic/Oncology guideline elements and postoperative outcomes in an international cohort.

Study Design: The study comprised 2101 patients undergoing elective gynecologic/oncology surgery between January 2011 and November 2017 in 10 hospitals across Canada, the United States, and Europe.

Medical-surgical nurses' perceived self-confidence and leadership abilities as first responders in acute patient deterioration events.

Aims And Objectives: To explore and understand medical-surgical nurses' perceived self-confidence and leadership abilities as first responders in recognising and responding to clinical deterioration prior to the arrival of an emergency response team.

Background: Patients are admitted to hospitals with multiple, complex health issues who are more likely to experience clinical deterioration. The majority of clinical deterioration events occur on medical-surgical units, and medical-surgical nurses are frequently the first healthcare professionals to identify signs and symptoms of clinical deterioration and initiate life-saving interventions.

Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH.

Purpose: This study tested the ability of lonidamine (LND), a clinically applicable inhibitor of monocarboxylate transporters (MCT), to thermally sensitise human melanoma cells cultured at a tumour-like extracellular pH (pHe) 6.7.

Materials And Methods: Human melanoma DB-1 cells cultured at pHe 6.

Combined methotrexate-dactinomycin: an effective therapy for low-risk gestational trophoblastic neoplasia.

Objective: The objective of this study is to examine the outcomes of combined chemotherapy using methotrexate and dactinomycin in the management of women with low-risk gestational trophoblastic neoplasia (GTN). The primary outcome is the total number of cycles of chemotherapy required to achieve a normal level of human chorionic gonadotropin (hCG). The secondary outcome is treatment-related toxicity.

Preoperative bowel preparation in gynecologic oncology: a review of practice patterns and an impetus to change.

Objectives: Preoperative mechanical bowel preparation (MBP) is commonly used in gynecologic oncology (GO). We wished to assess the practice patterns and beliefs within the Society of Gynecologic Oncologists of Canada (GOC), review the literature on MBP as applicable to GO surgeries, and construct recommendations specific to our subspecialty.

Methods: A 23-question, 10-minute Internet survey was sent to 110 GOC members regarding their use, rationale, and understanding of the literature pertaining to MBP for GO surgeries.

Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers.

Purpose: Metabolomics is a new, rapidly expanding field dedicated to the global study of metabolites in biological systems. In this article metabolomics is applied to find urinary biomarkers for breast and ovarian cancer.

Experimental Design: Urine samples were collected from early- and late-stage breast and ovarian cancer patients during presurgical examinations and randomly from females with no known cancer.

Society of obstetricians and gynaecologists of Canada junior member committee survey: future career plans of Canadian obstetrics and gynaecology residents.

Objective: Although the SOGC Strategic Directions 2006-2011 includes a commitment to the development of a human resource strategy for obstetrical and gynaecological care, little is known about the career plans of Canadian obstetrics and gynaecology residents. If we are to determine the needs of our profession, we must be aware of the expected practice patterns of future women's health care providers. The primary objective of this study was to evaluate the future career plans of Canadian obstetrics and gynaecology residents.

Suprapubic or urethral catheter: what is the optimal method of bladder drainage after radical hysterectomy?

Background: Lower urinary tract dysfunction is a common morbidity related to radical hysterectomy (RAH). Although transurethral catheterization (TUC) has traditionally been used for postoperative bladder drainage following RAH, suprapubic catheterization (SPC) is an alternative method that may be advantageous.

Objectives: To determine, by means of a retrospective cohort study, the incidence of urinary tract infection (UTI), duration of postoperative hospital stay, and time to trial of voiding in women catheterized suprapubically or transurethrally after RAH for early stage cervical cancer.

Autoimmune thrombocytopenia due to chronic lymphocytic leukemia treated with fludarabine.

Objective: To report a case of autoimmune thrombocytopenia due to chronic lymphocytic leukemia (CLL) treated with fludarabine.

Case Summary: A 68-year-old white woman with CLL was treated with oral chlorambucil. She subsequently presented with severe autoimmune thrombocytopenia purpura (ITP).