Publications by authors named "Tiffany W Huang"
Article Synopsis
- - The electrical synapse density (ESD) is a macromolecular complex involving neuronal gap junction channels, crucial for regulating electrical transmission and network function, but its protein makeup is not fully understood.
- - In zebrafish, the protein ZO1b, a component of the ESD, exists in three isoforms—ZO1b-Alpha, -Beta, and -Gamma—each with distinct functions and expression patterns, where Beta is essential for gap junction channel localization.
- - This research highlights the complexity of ESD by showing that distinct isoforms from a single gene can differentially contribute to the formation and function of electrical synapses, affecting overall neural development and behavior.
To restore central vision in patients with atrophic age-related macular degeneration, we replace the lost photoreceptors with photovoltaic pixels, which convert light into current and stimulate the secondary retinal neurons. Clinical trials demonstrated prosthetic acuity closely matching the sampling limit of the 100m pixels, and hence smaller pixels are required for improving visual acuity. However, with smaller flat bipolar pixels, the electric field penetration depth and the photodiode responsivity significantly decrease, making the device inefficient.
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- Researchers are improving the detection of cellular action potentials using new techniques that overcome the limitations of traditional methods, such as low temporal resolution in calcium imaging and issues with voltage indicators.
- The study presents a method called full-field interferometric imaging that measures tiny deformations (up to 3 nm) in the cell membrane during action potentials, using a technique synced with electrical recordings for accuracy.
- By employing high-speed imaging (50 kHz) and a sensitivity enhancement algorithm, this new approach enables the detection of action potentials optically without the need for external labels or electrodes, allowing for a clearer understanding of cellular activity.