Publications by authors named "Tiffany S Tufenkjian"
Article Synopsis
- An intergenic region on chromosome 4q31 linked to COPD (chronic obstructive pulmonary disease) susceptibility and lung function was studied, focusing on the gene HHIP, which shows different expression patterns in human and mouse lungs.
- Various molecular techniques like snATAC-seq and CRISPR/Cas9 were used to identify and manipulate regulatory elements affecting HHIP expression in human lung cells.
- The research found that a distal enhancer regulates HHIP expression, influenced by TGFβ, and reduced HHIP levels lead to enhanced epithelial-mesenchymal transition, suggesting a role in COPD development.
Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med
January 2024
Multiciliated cell (MCC) loss and/or dysfunction is common in the small airways of patients with chronic obstructive pulmonary disease (COPD), but it is unclear if this contributes to COPD lung pathology. To determine if loss of p73 causes a COPD-like phenotype in mice and explore whether smoking or COPD impact p73 expression. p73 mice were crossed with Shh-Cre mice to generate mice lacking MCCs in the airway epithelium.
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