Publications by authors named "Tiffany Mullet"
[The impact of oocyte cryopreservation time in oocyte donation on the clinical success rate].
Gynecol Obstet Fertil Senol
April 2023
Article Synopsis
- The study aimed to assess how the duration of storage affects the success rates of oocyte donation cycles by analyzing 156 cases from January 2012 to September 2021.
- Researchers classified the donated oocytes based on how long they had been cryopreserved, ranging from less than 3 months to over 2 years, and compared their thawing survival rates and fertilization outcomes.
- Results showed that while longer storage impacted the survival rates post-thaw, it did not significantly affect fertilization rates or clinical outcomes, indicating the need for further research with larger samples to confirm findings.
Article Synopsis
- Male infertility is a significant issue for couples globally, but the reasons behind unexplained cases (idiopathic) are still not well understood.
- Recent research indicates that circulating cell-free nucleic acids might be involved in male infertility and could provide insights into its causes.
- The review highlights the potential of these nucleic acids as biomarkers for diagnosing male infertility in clinical settings, paving the way for better understanding and treatment options.
Article Synopsis
- Several studies indicate a decline in sperm quality over the decades, prompting a study to evaluate how male factors such as sperm quality and paternal age affect IVF and ICSI outcomes.
- The study included data from IVF and ICSI treatments at Montpellier University Hospital from 2010 to 2015, analyzing primary outcomes like blastulation and pregnancy rates, alongside secondary outcomes like fertilization and early miscarriage rates.
- Results showed that severe oligospermia negatively impacted fertilization and blastulation rates, particularly in ICSI, and that paternal age over 51, coupled with maternal age over 37, also reduced pregnancy success rates, suggesting revised fertilization strategies for older couples or those with low sperm quality.
Article Synopsis
- Cell-free DNA (cfDNA) in follicular fluid (FF) is linked to ovarian reserve status and IVF outcomes, showing higher levels in patients with ovarian reserve disorders.
- A study involving 117 IVF patients found significant differences in cfDNA levels based on ovarian stimulation protocols and fertility medication dosages.
- CFDNA levels also emerged as a predictive factor for pregnancy outcomes, suggesting its potential as a biomarker to improve IVF success and female infertility management.