Publications by authors named "Tiffany J Lo"
Objective: Maintaining adequate drug adherence is crucial to ensure the HIV prevention benefits of pre-exposure prophylaxis (PrEP). We developed an enzymatic assay for rapidly measuring tenofovir-diphosphate (TFV-DP) concentrations-a metabolite that indicates long-term PrEP adherence.
Setting: The study was conducted at the Madison HIV Clinic at Harborview Medical Center in Seattle.
Article Synopsis
- Poor adherence to pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) can result in HIV acquisition and drug-resistant infections, highlighting the need for effective adherence monitoring.
- Traditional drug-level measurement methods, like liquid chromatography/mass spectrometry, are complex and costly, making them impractical for everyday clinical use.
- The REstrict assay offers a rapid and affordable alternative for measuring drug levels, using innovative techniques to assess adherence to PrEP and ART, potentially improving patient outcomes.