Publications by authors named "Tiffany George"
[Correction Notice: An Erratum for this article was reported in Vol 126(4) of (see record 2024-93961-001). In the article (https://doi.org/10.
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- Disparities in cancer treatment outcomes have been emphasized with recent advances in therapies, particularly in lung cancer, where sociodemographic and geographic factors affect patients' decisions to accept or decline chemotherapy.
- In a study analyzing data from the National Cancer Database, researchers found that factors such as older age, female sex, low income, lack of insurance, residence in New England, and higher comorbidity rates were linked to a higher likelihood of refusing treatment.
- To improve cancer care and reduce disparities, it is crucial to better understand the various influences on treatment decisions among patients.
Epigenetic ("above genetics") modifications can alter the gene expression without altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA methylation, histone methylation, histone acetylation, non-coding RNA, and mRNA methylation. Epigenetic-targeted agents have demonstrated clinical activities in hematological malignancies and therapeutic potential in solid tumors.
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- Some cancer patients require dual treatment involving VEGFR tyrosine kinase inhibitors and factor Xa inhibitors, but the safety of these combinations is not well understood.
- A study at The Ohio State University analyzed bleeding events in 86 patients receiving both therapies compared to those on factor Xa inhibitors alone, finding more significant bleeding incidents in the combined treatment group.
- The results indicated that concurrent treatment significantly increased the risk of overall and first-onset bleeding events, suggesting the need for caution in using these medications together.
Article Synopsis
- * A study analyzed data from 119,404 women aged 60 and older, revealing that those who had surgery had significantly better overall survival rates compared to those who didn’t.
- * The findings suggest that medically-fit elderly patients with this cancer type should undergo definitive surgery due to its considerable survival advantages.
Plasmacytoid dendritic cells (pDCs) play essential roles in directing immune responses. These cells may be particularly important in determining the nature of immune responses to viral infections in patients with allergic asthma as well those with other atopic diseases. The purposes of this study were 1) to compare the functional capacity of pDCs in patients with one type of allergic disorder, allergic asthma, and controls; 2) to determine whether IgE cross-linking affects antiviral responses of influenza-exposed pDCs; and 3) to determine whether evidence of counterregulation of FcepsilonRIalpha and IFN-alpha pathways exists in these cells.
View Article and Find Full Text PDFThe impact of IFN-alpha secretion on disease progression was assessed by comparing phenotypic changes in the lupus-prone B6.Sle1Sle2Sle3 (B6.Sle123) strain and the parental C57BL/6 (B6) congenic partner using an adenovirus (ADV) expression vector containing a recombinant IFN-alpha gene cassette (IFN-ADV).
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