Publications by authors named "Tiffany Garrett"
Methamphetamine (METH) addiction is associated with several neuropsychiatric symptoms. Little is known about the effects of METH on gene expression and epigenetic modifications in the rat nucleus accumbens (NAC). Our study investigated the effects of a non-toxic METH injection (20 mg/kg) on gene expression, histone acetylation, and the expression of the histone acetyltransferase (HAT), ATF2, and of the histone deacetylases (HDACs), HDAC1 and HDAC2, in that structure.
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- The study examined how chronic methamphetamine (METH) affects the brain's response to METH-induced gene expression in rats, focusing on immediate early genes (IEGs).
- Rats receiving chronic METH showed reduced expression of certain IEGs in the nucleus accumbens (NAc) after an acute METH challenge, while still showing increased levels of other IEGs like Nr4a1 and Nr4a3.
- The research indicates that different brain regions, such as the NAc and midbrain, respond differently to the effects of chronic and acute METH exposure, revealing complexities in how psychostimulants impact brain function.