Study Exploring the Effects of Daily Supplementation with 400 μg of Folic Acid on the Nutritional Status of Folate in Women of Reproductive Age.

Background: This investigation determines the nutritional state of serum and red blood cell (RBC) folate concentration and their relation with intake of folate, B ,and B , with serum vitamin B , and with genetic variants after provision of 400 μg/day of folic acid for 3 months to a group of 34 Colombian women of reproductive age.

Methods: We evaluated nutrient intake using 24-hr recall, assessing the levels of serum folate, RBC folate, serum B , and homocysteine, as well as determining genetic variants of the enzyme MTHFR (C677T and A1298C) and CβS (844ins68pb).

Results: The results show that following intake of 400 μg/day of folic acid, the risk of folate deficiency as seen in regular dietary intake disappears and the nutritional status of this nutrient is increased (p < 0.