Publications by authors named "Tiffany Burd"
Article Synopsis
- Children have shown strong immune responses to SARS-CoV-2 during various pandemic waves, with a significant increase in seropositivity from 34.2% after the first wave to 99.2% after the fifth wave, despite experiencing minimal severe illness.
- The study found that IgG antibodies developed through natural exposure were effective in protecting children from future infections, with varying levels of effectiveness against different variants, showing the highest protection against the Beta variant and the least against Omicron.
- Maternal seropositivity was linked to higher child seropositivity, indicating that the immune status of mothers plays a crucial role in the immune response of their children against COVID-19.
Background: The study aim was to determine whether associations of antenatal maternal anaemia with smaller corpus callosum, putamen, and caudate nucleus volumes previously described in children at age 2-3 years persist to age 6-7 years in the Drakenstein Child Health Study (DCHS).
Methods: This neuroimaging sub-study was nested within the DCHS, a South African population-based birth cohort. Pregnant women were enrolled (2012-2015) and mother-child dyads were followed prospectively.
Objective: To evaluate if in-utero HIV exposure is associated with adverse cardiometabolic health outcomes at 5-8 years of age.
Design: Prospective cohort study.
Methods: We enrolled a random sample of HIV-exposed but uninfected (HEU) and HIV-unexposed children from the Drakenstein Child Health study, a longitudinal birth cohort study in Cape Town, South Africa, in a cardiometabolic health pilot study.
Background: More than half the global population has been exposed to SARS-CoV-2. Naturally induced immunity influences the outcome of subsequent exposure to variants and vaccine responses. We measured anti-spike IgG responses to explore the basis for this enhanced immunity.
View Article and Find Full Text PDFObjectives: The role of Klebsiella pneumoniae (KP) in lower respiratory tract infection (LRTI) is not well studied. We longitudinally investigated KP colonization and its association with LRTI in a South African birth cohort.
Methods: We conducted a case-control study of infants who developed LRTI and age-matched controls, followed twice weekly through infancy.
Background: Low vitamin D levels may increase the risk of tuberculosis disease; however, previous observational cohort studies showed variable results. We investigated the relationship between vitamin D levels in infancy and subsequent development of tuberculosis disease throughout childhood.
Methods: We enrolled pregnant women at 20-28 weeks' gestation attending antenatal care in a periurban South African setting in the Drakenstein Child Health Study.