Publications by authors named "Tiera Grant"
J Cell Biol
December 2017
Article Synopsis
- Several receptor tyrosine kinase (RTK) ligands boost RhoA-guanosine triphosphate (GTP) levels in both normal and cancer cell lines, with this effect being linked to the activation of the AKT serine/threonine kinase.
- The increase in RhoA-GTP occurs because AKT phosphorylates specific serines in the DLC1 tumor suppressor, altering its structure and function.
- This change inhibits DLC1’s ability to regulate RhoA-GTP, leading to reduced tumor suppressor activity and making DLC1 a significant target for AKT in cancers that express it.
