Publications by authors named "Tien Tiep Nguyen"
The transmembrane proteins, CD47 and signal-regulatory protein α are overexpressed in cancer cells and macrophages, respectively, and facilitate the escape of cancer cells from macrophage-mediated phagocytosis. The immunomodulatory and targeting properties of CD47, the chemotherapeutic effects of dabrafenib (D), and the anti-programmed death-1 antibodies (PD-1) pave the way for effective chemoimmunomodulation-mediated anticancer combination therapy. In this study, CD47-conjugated, D-loaded human serum albumin (HSA) nanosystems were fabricated by modified nanoparticle albumin-bound technology.
View Article and Find Full Text PDFDespite the significant efforts in developing cancer vaccines, there are still numerous challenges that need to be addressed to ensure their clinical efficacy. Herein, a lymphatic dendritic cell (DC)-targeted artificial nanovaccine mimicking tumor cell membrane (ATM-NV) is developed to boost effector immune response and control immunosuppression simultaneously. The NVs are formulated with lipids, tumor cell membrane proteins, imiquimod (IMQ), and IL-10 siRNA.
View Article and Find Full Text PDFArticle Synopsis
- Senescent cells are key contributors to atherosclerosis and cardiovascular disease, but their specific markers are not well understood, hindering effective treatments.
- Recent findings have identified CD9 as a promoter of cellular senescence that worsens plaque formation in a specific mouse model (ApoE knockout mice).
- The study developed a new drug delivery system using CD9 antibody-modified nanoparticles that effectively target senescent cells, improve cell health, and reduce atherosclerosis progression by administering the anti-senescence drug rosuvastatin directly to affected areas.
Article Synopsis
- * A new strategy involves creating engineered exosomes that target T cells and stimulate their response against tumors while blocking inhibitory factors.
- * The developed bifunctional exosomes (EXO-OVA-mAb) enhance T-cell binding and activation, leading to significant tumor growth inhibition by improving the balance of effector T cells to regulatory T cells in tumors.