Publications by authors named "Tielun Tang"
Article Synopsis
- * Overexpression of USP44 inhibits cancer cell growth and promotes cell death by regulating the Wnt/β-catenin signaling pathway, notably increasing Axin1 and decreasing β-catenin, c-myc, and cyclin D1 levels.
- * USP44 interacts with Axin1, reducing its ubiquitination, and its ability to suppress CRC cell proliferation and enhance apoptosis is dependent on the presence of Axin1, making USP44 a potential target for CRC therapies. *
[Expression of TMEM16A in the colon of intractable functional constipation patients and its clinical implications].
Zhonghua Wei Chang Wai Ke Za Zhi
July 2015
Objective: To investigate the expression of TMEMl6A in the colon of intractable functional constipation patients and its clinical implications.
Methods: A total of 30 patients with intractable chronic functional constipation were selected as trial group (full thickness tissue of sigmoid colon), 30 patients with colon cancer as control group (distant tissues at least 5 cm away from cancer). Tissues from two groups were collected in our hospital from February 2012 to June 2014 and confirmed by pathological diagnosis.
[Establishment of rat slow transit constipation model by selective chemical ablation of the enteric plexus].
Zhonghua Wei Chang Wai Ke Za Zhi
May 2015
Objective: To establish an innovative rat model of slow transit constipation by selective chemical ablation of the colon enteric plexus.
Methods: Sprague Dawley rats, 5-6 weeks old, were randomly divided into normal control group, sham operation group, treatment group I, II, III, IIII. The normal control group did not receive treatment.