Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats.

Background: Nonalcoholic steatohepatitis (NASH) is characterized by fat accumulation in the hepatocyte, inflammation, liver cell injury, and varying degrees of fibrosis, and can lead to oxidative stress in liver. Here, we investigated whether Salidroside, a natural phenolic antioxidant product, can protect rat from liver injury during NASH.

Methods: NASH model was established by feeding the male SD rats with high-fat and high-cholesterol diet for 14 weeks.