Publications by authors named "Tie-Nan Chen"
The long-term patency rate of saphenous vein (SV) grafts is poor compared to arterial grafts. To investigate the effects of surgical preparation (distention) of SV on hydrogen sulfide (HS) released from the endothelium, human SV segments were harvested from 43 patients during coronary artery bypass surgery (CABG). Acetylcholine (ACh) induced relaxation that was inhibited by N-nitro-L-arginine + indomethacin and cysteine aminotransferase inhibitor aminooxyacetic acid in the normal SV.
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- The study aims to explore how hydrogen sulfide (HS) affects the internal mammary arteries (IMA) and its relationship with specific enzymes like endothelial nitric oxide synthase (eNOS) and phosphodiesterase (PDE)5A.
- Researchers conducted experiments using IMA samples from patients undergoing coronary artery bypass grafting (CABG) to assess their relaxation responses to acetylcholine and a HS donor, NaHS, along with examining the distribution of certain enzymes involved in HS production.
- Results indicated that HS plays a significant role in endothelial function by promoting eNOS phosphorylation and inhibiting PDE5A activity, suggesting potential new treatment approaches for vascular complications in CABG surgeries.
Homocysteine (Hcy) is an independent risk factor for endothelial dysfunction in cardiovascular diseases. We hypothesized that the eNOS transcription enhancer AVE3085 may protect the endothelial function damaged by Hcy in the human internal mammary artery (IMA). Cumulative concentration-relaxation curves to acetylcholine (-10 to -4.
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- * Out of 45 patients undergoing surgery for TR from 1996 to 2008, a significant portion experienced right heart failure and atrial fibrillation, with most having undergone mitral valve replacements.
- * Surgical techniques used included tricuspid valve repair and replacement, with postoperative results showing improved heart function, underscoring the importance of addressing TR during mitral valve surgeries to prevent serious complications.
Objectives: The strategies of repair of tetralogy of Fallot change with the age of patients. In children older than 4 years and adults, the optimal strategy may be to use different method of reconstruction of the right ventricular outflow tract from those followed in younger children, so as to avoid, or reduce, the pulmonary insufficiency that is increasingly known to compromise right ventricular function.
Methods: From April, 2001, through May, 2008, we undertook complete repair in 312 patients, 180 male and 132 female, with a mean age of 11.