Facile Solvothermal Preparation of MnCuO Microspheres: Excellent Electrocatalyst for Real-Time Detection of HO Released from Live Cells.

Hydrogen peroxide (HO) is an eminent biomarker in pathogenesis; a selective, highly sensitive real-time detection of HO released from live cells has drawn a significant research interest in bioanalytical chemistry. Binary transition-metal oxides (BTMOs) displayed a recognizable benefit in enhancing the sensitivity of HO detection; although the reported BTMO-based HO sensor's detection limit is still insufficient, it is not appropriate for in situ profiling of trace amounts of cellular HO. In this paper, we describe an efficient, reliable electrochemical biosensor based on MnCuO (MCO) microspheres to assay cellular HO.

Three-dimensional plotted alginate fibers embedded with diclofenac and bone cells coated with chitosan for bone regeneration during inflammation.

Alginate hydrogel fibers embedded with bone cells and diclofenac were coated with a layer of chitosan hydrogel and made into a porous scaffold by three-dimensional (3D) printing for drug release and bone regeneration. It was hypothesized that the chitosan coating could improve the scaffold's drug retention and release properties and biocompatibility. Macrophage cells were stimulated and cocultured with the scaffold.