With advancements in mobile robot technology, wheel-legged robots have emerged as promising next-generation mobile solutions, reducing design costs and enhancing adaptability in unstructured environments. As underactuated systems, their balance control has become a prominent research focus. Despite there being numerous control approaches, challenges remain.
View Article and Find Full Text PDFPanax notoginseng has gained attention for its potential efficacy and mechanisms in skin whitening and spot removal. In this study, we investigated the effects of pre-columnar saponins and polysaccharides from the roots, as well as pre-columnar saponins and flavonoids from the stems and leaves, in the prevention and treatment of melasma. We further explored their molecular mechanisms, focusing on the Nrf2/ARE signaling pathway.
View Article and Find Full Text PDFFeline calicivirus (FCV) is one of the most common viral pathogens in domestic cats worldwide, which mainly causes upper respiratory tract infections in felines and seriously threatens the health of felines. Consequently, it is crucial to establish a rapid detection method to efficiently take control and prevent the spread of FCV. To construct the Cas13a-RAA-LFD reaction system, this study specifically designed recombinase-aided amplification (RAA) primers added with a T7 promoter and CRISPR RNA (crRNA), which were both based on the FCV relatively conserved sequence.
View Article and Find Full Text PDFAs indispensable components of vaccines, adjuvants play a critical role in inducing potent immune responses. In our previous study, we isolated and purified a water-soluble polysaccharide from Poria cocos (PCP), and found that the PCP had the potential to act as an immunostimulant to induce a balanced Th1/Th2 immune response. However, the PCP showed effective immunomodulatory activity only at high concentrations.
View Article and Find Full Text PDFVascular stents have many applications in treating arterial stenosis and other vascular-related diseases. The ideal vascular stent for clinical application should have radial support and axial bending mechanical properties that meet the requirements of vascular deformation coordination. The materials used for vascular stents implanted in the human body should have corresponding biocompatibility to ensure that the stents do not cause coagulation, hemolysis, and other reactions in the blood.
View Article and Find Full Text PDFDue to their safety and efficacy, aluminium salts (Alum) are considered the most important adjuvants in human vaccines. However, Alum adjuvants are unable to elicit a cellular immune response, which is vital for the prevention of various chronic infectious diseases and cancers. Herein, we isolated and purified a water-soluble polysaccharide from Chinese yam, named CYP, which was primarily composed of →4)-α-D-Glcp-(1→, →4,6)-α-D-Glcp-(1→, and α-D-Glcp-(1→.
View Article and Find Full Text PDFAvian leukemia virus (ALV) is one of the main pathogens of poultry tumor diseases, and has caused significant economic losses to the poultry industry since its discovery. Therefore, establishing a rapid detection method is essential to effectively prevent and control the spread of ALV. In this study, specific CRISPR RNA (crRNA) and recombinase-aided amplification (RAA) primers with T7 promoter were designed based on the relatively conserved sequence of avian leukemia virus.
View Article and Find Full Text PDFDefecation care for disabled patients is a major challenge in health management. Traditional post-defecation treatment will bring physical injury and negative emotions to patients, while existing pre-defecation forecasting care methods are physically intrusive. On the basis of exploring the mechanism of defecation intention generation, and based on the characteristic analysis and clinical application of bowel sounds, it is found that the generation of desire to defecate and bowel sounds are correlated to a certain extent.
View Article and Find Full Text PDFUnderstanding the shared and divergent mechanisms across antidepressant (AD) classes and probiotics is critical for improving treatment for mood disorders. Here we examine the transcriptomic effects of bupropion (NDRI), desipramine (SNRI), fluoxetine (SSRI) and a probiotic formulation (Lacidofil®) on 10 regions across the mammalian brain. These treatments massively alter gene expression (on average, 2211 differentially expressed genes (DEGs) per region-treatment combination), highlighting the biological complexity of AD and probiotic action.
View Article and Find Full Text PDFBackground: To investigate the effectiveness of the intervention with critical value management and push short messaging service (SMS), and to determine improvement in the referral rate of patients with positive hepatitis C antibody (anti-HCV).
Methods: No intervention was done for patients with positive anti-HCV screening results from 1 January 2015 to 31 October 2021. Patients with positive anti-HCV results at our hospital from 1 November 2021 to 31 July 2022 were informed vide critical value management and push SMS.
Enhalus acoroides, the largest seagrass species in terms of morphology, has been observed to be declining significantly. In an effort to restore seagrass meadows, we conducted a transplantion utilizing dislodged rhizome fragments of E. acoroides as the donor materials.
View Article and Find Full Text PDFTo address traditional impedance control methods' difficulty with obtaining stable forces during robot-skin contact, a force control based on the Gaussian mixture model/Gaussian mixture regression (GMM/GMR) algorithm fusing different compensation strategies is proposed. The contact relationship between a robot end effector and human skin is established through an impedance control model. To allow the robot to adapt to flexible skin environments, reinforcement learning algorithms and a strategy based on the skin mechanics model compensate for the impedance control strategy.
View Article and Find Full Text PDFPurpose: The study aimed to investigate potential risk factors for emergence delirium (ED) in pediatric patients after tonsillectomy and adenoidectomy (T&A).
Methods: This prospective, single-center observational study enrolled children aged 3-7 years who underwent T&A under general anesthesia. ED was assessed according to DSM-IV or V criteria.
To rapidly, specifically, and sensitively detect avian influenza virus (AIV), this research established a visual detection method of recombinase-aided amplification (RAA) based on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated proteins 13a (Cas13a) system. In this study, specific primers and CRISPR RNA (crRNA) were designed according to the conservative sequence of AIV Nucleprotein (NP) gene. RAA technology was used to amplify the target sequence, and the amplification products were visually detected by lateral flow dipstick (LFD).
View Article and Find Full Text PDFThere are still limitations in artificial bone materials used in clinical practice, such as difficulty in repairing large bone defects, the mismatch between the degradation rate and tissue growth, difficulty in vascularization, an inability to address bone defects of various shapes, and risk of infection. To solve these problems, our group designed stereolithography (SLA) 3D-printed calcium silicate artificial bone improved by a calcium sulfate-Cu delivery system. SLA technology endows the scaffold with a three-dimensional tunnel structure to induce cell migration to the center of the bone defect.
View Article and Find Full Text PDFPhys Chem Chem Phys
November 2023
High-performance thermoelectric materials in theoretical and experimental research are mostly composed of expensive, scarce, heavy elements and rarely of single light elements, which severely limit their application and development. Based on density functional and semiclassical Boltzmann transport theory, we determine that a stable phosphorene allotrope, named Tri-Tri phosphorene, has super-high electron mobility (23845.29 cm V s) much higher than those of most two-dimension materials.
View Article and Find Full Text PDFComb Chem High Throughput Screen
October 2024
Background: Gout is a common inflammatory arthritis, which is mainly caused by the deposition of monosodium urate (MSU) in tissues. Transcriptomics was used to explore the pathogenesis and treatment of gout in our work.
Objective: The objective of the study was to analyze and validate potential therapeutic targets and biomarkers in THP-1 cells that were exposed to MSU.
A high-power near-infrared wavelength-modulated differential photoacoustic spectroscopy sensor for parts-per-billion (ppb) level methane detection is reported by using a homemade Raman fiber optical amplifier. A commercial 1653.7 nm continuous wave distributed feedback laser is employed as a seed source to excite a high light power of ∼550 , which greatly improves sensor performance.
View Article and Find Full Text PDFThe efficiency of communication across workers is a significant factor that affects the performance of federated learning. Though periodic communication strategy is applied to reduce communication rounds in training, the communication cost is still high when the training data distributions are not independently and identically distributed (non-IID) which is common in federated learning. Recently, some works introduce variance reduction to eliminate the effect caused by non-IID data among workers.
View Article and Find Full Text PDFAs an innovative form of stimulus-response materials, organic-inorganic hybrid phase transition materials have become a wonderful contender in the field of functional electronic equipment due to their versatile structure, intensive functions and straightforward preparation. However, the targeted regulation and optimization of the electrical/optical response, along with the establishment of regular structure-performance relationships, pose significant challenges in meeting the diverse demands of practical applications over an extended period. Herein, we conducted a systematic investigation into the role of lattice void occupancy in regulating phase transition temperature () and related optical/electrical bistability.
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