Flexible Sono-Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling.

Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially the functional recovery of skin appendages such as sweat glands in burn patients. However, current approaches mostly rely on the use of exogenous materials or chemicals to stimulate cell proliferation and migration, while the remodeling of a pro-regenerative microenvironment remains challenging. Herein, we developed a flexible sono-piezo patch (fSPP) that aims to create an endogenous regenerative microenvironment to promote the repair of sweat glands in burn wounds.

Inhibition Effect of TiCT MXene on Ice Crystals Combined with Laser-Mediated Heating Facilitates High-Performance Cryopreservation.

The phenomena of ice formation and growth are of great importance for climate science, regenerative medicine, cryobiology, and food science. Hence, how to control ice formation and growth remains a challenge in these fields and attracts great interest from widespread researchers. Herein, the ice regulation ability of the two-dimensional MXene TiCT in both the cooling and thawing processes is explored.

Synergistic Ice Inhibition Effect Enhances Rapid Freezing Cryopreservation with Low Concentration of Cryoprotectants.

Despite recent advances in controlling ice formation and growth, it remains a challenge to design anti-icing materials in various fields from atmospheric to biological cryopreservation. Herein, tungsten diselenide (WSe)-polyvinyl pyrrolidone (PVP) nanoparticles (NPs) are synthesized through one-step solvothermal route. The WSe-PVP NPs show synergetic ice regulation ability both in the freezing and thawing processes.

Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges.

Cryopreservation technology has developed into a fundamental and important supporting method for biomedical applications such as cell-based therapeutics, tissue engineering, assisted reproduction, and vaccine storage. The formation, growth, and recrystallization of ice crystals are the major limitations in cell/tissue/organ cryopreservation, and cause fatal cryoinjury to cryopreserved biological samples. Flourishing anti-icing materials and strategies can effectively regulate and suppress ice crystals, thus reducing ice damage and promoting cryopreservation efficiency.