Publications by authors named "Ticiane F Damasceno"
Insect Biochem Mol Biol
October 2017
Article Synopsis
- Cathepsins L are important digestive peptidases in the beetle Tenebrio molitor, with two specific enzymes (TmCAL2 and TmCAL3) having their 3D structures characterized.
- The study focused on TmCAL3 to investigate its substrate specificity and catalytic properties by testing it on 64 oligopeptides and analyzing how its structure influences its function.
- Results revealed that TmCAL3 differs in specificity from human cathepsins L and provided insights into its binding and catalytic mechanisms, with observations suggesting its transport to the midgut relies on overexpression due to the absence of certain lysosomal sorting machinery in the beetle.
