Publications by authors named "Tician Schnitzler"
Article Synopsis
- - This study investigates the effectiveness of an artificial intelligence (AI) algorithm in detecting incidental pulmonary embolisms (iPEs) in chest CT scans, comparing results before and after the AI implementation.
- - It analyzed data from 5,298 CT scans, revealing that prior to AI use, radiologists missed around 50% of iPE cases, with the AI achieving high sensitivity (95%) and specificity (99%) in identifying suspicious iPEs.
- - The study also aimed to assess the anatomical distribution of missed iPE cases and evaluate mortality rates in patients within 90 days following the different detection methods.
Background: After breast conserving surgery (BCS), surgical clips indicate the tumor bed and, thereby, the most probable area for tumor relapse. The aim of this study was to investigate whether a U-Net-based deep convolutional neural network (dCNN) may be used to detect surgical clips in follow-up mammograms after BCS.
Methods: 884 mammograms and 517 tomosynthetic images depicting surgical clips and calcifications were manually segmented and classified.
The effect of grainyhead-like transcription factor 3 (GRHL3) on cancer development depends on the cancer subtypes as shown in tumor entities such as colorectal or oral squamous cell carcinomas. Here, we analyzed the subtype-specific role of GRHL3 in bladder carcinogenesis, comparing common urothelial carcinoma (UC) with squamous bladder cancer (sq-BLCA). We examined GRHL3 mRNA and protein expression in cohorts of patient samples, its prognostic role and its functional impact on tumorigeneses in different molecular and histopathological subtypes of bladder cancer.
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- High-grade non-muscle-invasive bladder cancer (HG NMIBC) patients have a high risk of progressing to muscle invasive cancer, and there is a need for new bladder-preserving treatments.
- Recent approvals of enfortumab vedotin, which targets NECTIN4, show potential for treating advanced bladder cancer, but more research is needed on NECTIN4 in HG NMIBC.
- A study found that NECTIN4 positivity was high (91% overall) in various HG NMIBC subgroups, with significant differences in expression levels, suggesting that NECTIN4-targeted therapies could be beneficial, particularly for patients with carcinoma in situ (CIS) and pure papillary tumors.
Purpose: Non-invasive high-grade (HG) bladder cancer is a heterogeneous disease that is characterized insufficiently. First-line Bacillus Calmette-Guérin instillation fails in a substantial amount of cases and alternative bladder-preserving treatments are limited, underlining the need to promote a further molecular understanding of non-invasive HG lesions. Here, we characterized pure HG papillary urothelial bladder cancer (pure pTa HG), a potential subgroup of non-invasive HG bladder carcinomas, with regard to molecular subtype affiliation and potential for targeted therapy.
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