Publications by authors named "Tibor J Kovacs"
IgA nephropathy (IgAN) is the most common primary glomerular disease. Endothelin-1 (ET-1) is one of the strongest vasoconstrictor materials in the blood. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is associated with renal function and poor outcomes in chronic kidney disease (CKD).
View Article and Find Full Text PDFBackground: Patients with IgA nephropathy (IgAN), a chronic kidney disease (CKD), are significantly more likely to have cardiovascular (CV) mortality and morbidity than the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The purpose of this study was to determine how metabolic characteristics in a homogeneous population of CKD patients relate to prognosis.
View Article and Find Full Text PDFIgA nephropathy (IgAN) is associated with chronic inflammation. Platelet-related parameters, such as the platelet (PLT) count, platelet-to-albumin ratio (PAR), and platelet-to-lymphocyte ratio (PLR), were examined as potential prognostic indicators for renal and cardiovascular (CV) outcomes in IgAN. We were interested in whether platelet-related parameters are risk factors for ESKD and CV events in IgAN patients.
View Article and Find Full Text PDFAim: In chronic kidney disease, IgA nephropathy, and left ventricular diastolic dysfunction have prognostic significance as well. However, the relationship between diastolic dysfunction, arterial stiffness, and renal function has not been fully elucidated.
Methods: 79 IgA nephropathy patients (aged 46 ± 11 years) and 50 controls were investigated.
Article Synopsis
- Cardiovascular mortality is a major concern in chronic kidney disease and IgA nephropathy, prompting this study to identify biomarkers that indicate disease outcomes based on vascular and heart changes.
- The study involved 90 IgAN patients, measuring NT-proBNP for heart failure and CITP for fibrosis, revealing significantly higher levels of NT-proBNP, arterial stiffness (cfPWV), and central aortic systolic pressure in patients with more advanced kidney disease (CKD 3-5).
- The findings suggest that NT-proBNP and CITP can help identify IgAN patients at risk for heart issues and related vascular diseases, with eGFR being the only independent predictor of NT-proBNP levels.
Introduction: In chronic kidney disease (CKD), like in IgA nephropathy (IgAN), cardiovascular (CV) mortality and morbidity are many times higher than in the general population, and left ventricular hypertrophy (LVH) is an independent risk factor for CV disease. This follow-up study investigated the association between left ventricular mass index (LVMI) and renal or cardiovascular outcomes.
Methods: We examined 118 IgAN patients prospectively.
We report on the clinical and imaging features--including CT and MRI--of nodular fasciitis with cortical involvement in the shoulder. Nodular fasciitis is a commonly encountered benign soft-tissue fibrous tumor that typically involves the upper extremity and may be mistaken for a sarcomatous lesion because of its rapid growth. Lesions of the intramuscular subtype, because of their large size and deep location, usually require preoperative MR-imaging.
View Article and Find Full Text PDFBackground: HDL-associated paraoxonase (PON1) reduces oxidation of lipids in LDL, and activity is inversely related to coronary heart disease risk with a beneficial effect on the development of atherosclerosis. Risk factors associated with atherosclerosis, such as hypertension, dyslipidemia and smoking, also promote the progression of chronic glomerulonephritides which may therefore be associated with perturbations in PON1 activity.
Methods: We performed a genetic association study in patients with IgA nephropathy (IgAN) (n=115) compared with control subjects (n=118).