Publications by authors named "Tiberiu Nistor"
Article Synopsis
- - Hashimoto's thyroiditis (HT) is a significant autoimmune thyroid disease where patients often present with asthenia (fatigue), presenting challenges in differentiating it from other conditions; this study aimed to analyze the relationship between HT and asthenia in newly diagnosed patients.
- - Conducted between July 2022 and July 2023 across multiple university hospitals, the study included 120 patients, divided into an asthenia group (49.2%) and a non-asthenia group, discovering that asthenia was linked to a higher incidence of headaches and hypothyroidism but thyroid function tests were similar between both groups.
- - The findings suggest that asthenia may not be a strong indicator of thyroid dysfunction
Article Synopsis
- A less-than-total thyroidectomy reduces the risk of complications like hypothyroidism and nerve injury, but may necessitate "redo" surgery if unexpected cancer or disease progression is found post-op.
- The review analyzed recent English-language studies on redo thyroid surgeries from 2020 to 2024, focusing on various surgical techniques and complications.
- Findings highlighted the rise in robotic-assisted surgeries and the need for more comprehensive studies to improve decision-making and risk assessment for redo interventions.
Article Synopsis
- Non-functioning adrenal incidentalomas (NFAIs) are associated with a higher risk of glucose profile issues, especially type 2 diabetes mellitus (T2DM), though clear links to Cushing's syndrome aren't fully established.
- A comprehensive literature review analyzed 37 studies involving over 17,000 individuals, finding T2DM prevalence in NFAIs with mild autonomous cortisol secretion (MACS) ranged from 12% to 44%, with some studies showing rates as high as 45.2%.
- Comparisons between NFAIs and non-tumor controls indicated increased T2DM rates in NFAIs, and while some studies examined Cushing's syndrome, results regarding glucose profile anomalies were inconsistent.
Turning Points in Cross-Disciplinary Perspective of Primary Hyperparathyroidism and Pancreas Involvements: Hypercalcemia-Induced Pancreatitis, Gene-Related Tumors, and Insulin Resistance.
Mara Carsote Claudiu Nistor Ana-Maria Gheorghe Oana-Claudia Sima Alexandra-Ioana Trandafir Tiberiu Vasile Ioan Nistor
Int J Mol Sci
June 2024
Article Synopsis
- - Analysis focused on three key aspects of pancreas involvement in primary hyperparathyroidism (PHP): hypercalcemia-induced pancreatitis (HCa-P), MEN1-related neuroendocrine tumors (NETs), and insulin resistance, utilizing studies from PubMed between January 2020 and January 2024.
- - Findings showed that HCa-P had links to NETs and pancreatitis, with case reports revealing instances in pregnant individuals and cases of parathyroid carcinoma; MEN1-related studies indicated a high recurrence rate after surgery and significant associations among PHP and pancreatic NETs.
- - Insulin resistance analysis indicated that about one-third of adults could be prediabetic, with a notable correlation between serum calcium levels and insulin resistance
The regional incidence of 21-hydroxylase deficiency, its mutational spectrum and the correlation of genotype and phenotype has been studied by European, American and Latin-American groups. However, little information is known about the molecular background of the disease in patients from Central-Eastern Europe. The present study aimed to genotype a group of patients from Transylvania, the north-western part of Romania, in order to gain some insight into the molecular pattern and the genotype-phenotype correlation of congenital adrenal hyperplasia (CAH) in this region.
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