Publications by authors named "Tiara Fryer Harris"
Article Synopsis
- The larval zebrafish model is valuable across various research fields, especially in studying neuropsychiatric, developmental, and toxicological behaviors through behavioral analysis.
- A study investigated how different testing arena sizes and embryo media affect key behaviors like acoustic startle sensitivity and locomotion in zebrafish larvae, finding that larger arenas reduce startle sensitivity and increase movement.
- Specific components in embryo media also significantly influenced behaviors, and rearing mutant zebrafish for CHARGE syndrome in various media showed changes in observed phenotypes, highlighting the need for standardized approaches in zebrafish behavioral studies.
The larval zebrafish is a highly versatile model across research disciplines, and the expanding use of behavioral analysis has contributed to many advances in neuro-psychiatric, developmental, and toxicological studies, often through large-scale chemical and genetic screens. In the absence of standardized approaches to larval zebrafish behavior analysis, however, it is critical to understand the impact on behavior of experimental variables such as the size of testing arenas and the choice of embryo medium. Using a custom-built, modular high-throughput testing system, we examined the effects of 4 testing arena sizes and 11 types of embryo media on conserved sensorimotor behaviors in zebrafish larvae.
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