Publications by authors named "Tiara D Tillis"
Biochemistry
December 2020
Article Synopsis
- In the MAPK pathway, the V600E mutation in B-Raf kinase leads to constant activation, resulting in excessive activity of downstream kinases MEK and ERK, contributing to melanoma and other cancers.
- Research indicates that existing drugs often fail due to resistance and can paradoxically activate B-Raf; therefore, new drugs targeting allosteric sites are necessary.
- By studying a specific α-helix on B-Raf crucial for its interaction with MEK, the research identifies potential new drug targets to inhibit B-Raf's oncogenic effects in melanoma.
