A novel target-triggered signal chemiluminescence kit for thrombin detection based on fusiform Au/MIL-53(Fe).

In this work, a fusiform Au/MIL-53(Fe) catalyst was used to construct a chemiluminescence (CL) kit for the sensitive and rapid detection of thrombin (THR). The porous silica microspheres encapsulated with luminol in holes by thrombin aptamer (THR-APT/Luminol/SPSiO) and the fusiform Au/MIL-53(Fe) modified with thrombin aptamer complementary chains (Au/MIL-53(Fe)-SSDNA) were prepared. Then, a CL kit for THR detection was constructed by using the prepared composites.

A Chemiluminescence Sensor for the Detection of α-Fetoprotein and Carcinoembryonic Antigen Based on Dual-Aptamer Functionalized Magnetic Silicon Composite.

In this work, a dual-aptamer functionalized magnetic silicon composite was prepared and used to construct a chemiluminescence (CL) sensor for the detection of α-fetoprotein (AFP) and carcinoembryonic antigen (CEA). First, SiO@FeO was prepared, and polydiallyl dimethylammonium chloride (PDDA) and AuNPs were sequentially loaded on SiO@FeO. Subsequently, the complementary strand of CEA aptamer (cDNA) and the aptamer of AFP (Apt) were attached to AuNPs/PDDA-SiO@FeO.