Publications by authors named "Tianzhu Yuan"
Background: Esophageal perforation has been one of the serious clinical emergencies, because of the high mortality and complication rates. However, the current prognosis of esophageal perforation and the outcomes of available treatment methods are not well defined. This study attempted to pool the immediate outcomes of esophageal perforation in the past 2 decades.
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- MiR-21 is identified as a common proto-oncogene and a potential biomarker for cancer diagnosis, although its diagnostic accuracy remains unclear.
- A meta-analysis of 48 studies involving over 5,800 participants determined that circulating miR-21 has a sensitivity of 76% and specificity of 82% for diagnosing various cancers.
- The validation test indicated significantly higher serum miR-21 levels in endometrial cancer and benign lesion patients compared to healthy controls, supporting the idea that miR-21 could serve as a promising biomarker for endometrial carcinoma.
Background: Some studies have supposed that glutathione S-transferases (GSTs) may be involved in detoxification of carcinogens, especially from tobacco smoke. Therefore, polymorphism of GSTs has been considered as potential protectors of individual cancer risk. The objective of this study is to investigate the relationship between genetic polymorphism of GSTT1 and inherent susceptibility to lung cancer in Han population in Sichuan, China.
View Article and Find Full Text PDFBackground: Genetic polymorphism in metabolic enzymes, which are involved in metabolism of environmental carcinogens, have been thought to be related to susceptibility of lung cancer. The aim of this study is to investigate the cytochrome P450 2D6(CYP2D6) genetic polymorphism distribution in Han population in Sichuan, China, and to evaluate the relationship between CYP2D6 genetic polymorphism and lung cancer susceptibility.
Methods: PCR-RFLP was used to identify CYP2D6ch genotypes among 150 patients with primary lung cancer and 152 healthy controls, in Han population in Sichuan, China, and case-control study was used to analyze the relationship between genetic polymorphism and lung cancer susceptibility.
[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer].
Zhongguo Fei Ai Za Zhi
February 2005
Background: Lung cancer is the leading cause of malignant tumor death among Chinese population. It has been known that the development of lung cancer may be associated with genetic po-lymorphism of some lung cancer related genes. The aim of this study is to evaluate the relationship between genetic polymorphism of metabolizing enzymes and susceptibility of lung cancer in Chinese population.
View Article and Find Full Text PDFBackground: To investigate the diagnosis and treatment of pulmonary sclerosing hemangioma (PSH).
Methods: The clinical features, radiographic manifestations and treatment of 21 patients with PSH were reviewed.
Results: None of the 21 patients was diagnosed as PSH preoperatively.