177Lu Radiolabeled Polydopamine Decorated with Fibroblast Activation Protein Inhibitor for Locoregional Treatment of Glioma.

Radionuclide therapy is expected to be a powerful tool for glioma treatment. Here, we introduce a novel nuclear nanomedicine based on polydopamine (PDA), incorporating fibroblast activation protein inhibitor (FAPI) and macrocyclic chelator (DOTA) for specific cancer targeting and 177Lu labeling. The synthesized nanoradiopharmaceutical, 177Lu-DOTA-PEG-PDA-FAPI, exhibits good stability in serum, saline and PBS over 5 days.

Strong Affinity between Astatine and Silver: An Available Approach to Anchoring At in Nanocarrier for Locoregional Oncotherapy.

Recently, At-related endoradiotherapy has emerged as an important oncotherapy strategy. Conjugating At with a nanocarrier provides a vital candidate for radionuclide therapy of various malignant tumors. In this study, we proposed utilizing the intrinsically high affinity of heavy halogens and sulfhydryl compounds for metallic silver to achieve highly efficient conjugation between At and Ag-based nanoparticles in a simple way.

At radiolabeled APBA-FAPI for enhanced targeted-alpha therapy of glioma.

Fibroblast activation protein-α (FAPα) is highly expressed in tumor-associated cells and has become one of the most attractive targeting sites in cancer diagnosis and therapy. To ameliorate the rapid metabolism of FAPα inhibitor (FAPI), here, a multifunctional binding agent was introduced to simultaneously achieve At radiolabeling and tumor retention prolongation of corresponding radiolabeled drug. At-APBA-FAPI was successfully synthesized by conjugating At with the designed FAPI carrier in satisfactory radiochemical yield (>60 %).

A review on characteristics and mitigation strategies of indoor air quality in underground subway stations.

Due to the rapidly increasing ridership and the relatively enclosed underground space, the indoor air quality (IAQ) in underground subway stations (USSs) has attracted more public attention. The air pollutants in USSs, such as particulate matter (PM), CO and volatile organic compounds (VOCs), are hazardous to the health of passengers and staves. Firstly, this paper presents a systematic review on the characteristics and sources of air pollutants in USSs.

Release behavior and mechanism of uranium and thorium from Ta-Nb tailings under simulated rainfall in Jiangxi Province, China.

Tantalum-niobium ore belongs to associated radioactive ore, which is accompanied by a certain amount of radioactive uranium and thorium. The remaining slag is enriched with a large number of radionuclides; after weathering, natural rainfall, and surface water scouring, radioactive elements such as uranium, thorium, and some heavy metal elements are exposed or washed into the soil, which poses a threat to the ecological environment and human health. In this study, for characterization analysis during, before, and after leaching, dynamic simulation experiment was carried out on a Ta-Nb slag sample in Jiangxi, China.