Basic Science and Pathogenesis.

Background: MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression, but we have limited insight into their role in age-related cerebral pathologies. Here, we investigated the association between miRNAs and nine age-related cerebral pathologies in participants of the ROS/MAP cohorts.

Method: MiRNA sequencing was performed on samples from the dorsolateral prefrontal cortex of 617 brain donors from participants of the ROS/MAP cohorts.

Fast Graph Generation via Spectral Diffusion.

Generating graph-structured data is a challenging problem, which requires learning the underlying distribution of graphs. Various models such as graph VAE, graph GANs, and graph diffusion models have been proposed to generate meaningful and reliable graphs, among which the diffusion models have achieved state-of-the-art performance. In this paper, we argue that running full-rank diffusion SDEs on the whole graph adjacency matrix space hinders diffusion models from learning graph topology generation, and hence significantly deteriorates the quality of generated graph data.