Research on the brand image of iOS and Android smart phone operating systems based on mixed methods.

Introduction: To analyze the differences in system functions, interaction behaviors and user experience between iOS and Android smart phone operating system, and then study the differences in their brand images, so as to provide theory and research method for shaping corporate brand images from the perspective of product interaction design.

Methods: This study was divided into three stages. In the first stage, the functional information architecture of iOS and Android smart phone operating system are studied comparatively by using information visualization methods.

Further enhanced dissolution and oral bioavailability of docetaxel by coamorphization with a natural P-gp inhibitor myricetin.

The current study aims to improve the dissolution and oral bioavailability of a BCS IV drug docetaxel (DOC) by coamorphization with a natural P-gp inhibitor myricetin (MYR). A single-phase coamorphous form of DOC with MYR in a 1:1 molar ratio was prepared by solvent-evaporation method and characterized by differential scanning calorimetry, thermogravimetric analysis and powder X-ray diffraction. In comparison to crystalline DOC, amorphous DOC showed similar equilibrium aqueous solubility, temporary improvement in the intrinsic dissolution rate (IDR) and supersaturated dissolution; while coamorphous DOC-MYR exhibited a persistent enhanced IDR and prolonged highly supersaturated dissolution.

Enhanced oral bioavailability of docetaxel in rats combined with myricetin: In situ and in vivo evidences.

The purpose of this study was to investigate the effect of myricetin on the pharmacokinetics of docetaxel in rats. In comparison to oral docetaxel alone (40mg/kg), the bioavailability of docetaxel could be significantly enhanced by 1.6-2.