Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer.

Multitarget medications represent an appealing therapy against the disease with multifactorial abnormalities─cancer. Therefore, simultaneously targeting son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR), two aberrantly expressed proteins crucial for the oncogenesis and progression of prostate cancer, may achieve active antitumor effects. Here, we discovered dual SOS1/EGFR-targeting compounds via pharmacophore-based docking screening.

Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting.

There are few tumor cell subpopulations with stem cell characteristics in tumor tissue, defined as cancer stem cells (CSCs) or cancer stem-like cells (CSLCs), which can reconstruct neoplasms with malignant biological behaviors such as invasiveness via self-renewal and unlimited generation. The microenvironment that CSCs depend on consists of various cellular components and corresponding medium components. Among these factors existing at a variety of levels and forms, cytokine networks and numerous signal pathways play an important role in signaling transduction.

Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation.

Dual inhibition of tubulin and neuropilin-1 (NRP1) may become an effective method for cancer treatment by simultaneously killing tumor cells and inhibiting tumor angiogenesis. Herein, we identified dual tubulin/NRP1-targeting inhibitor TN-2, which exhibited good inhibitory activity against both tubulin polymerization (IC = 0.71 ± 0.

Exploration of SERPINA family functions and prognostic value in breast cancer based on transcriptome and in vitro analysis.

Breast cancer poses a significant risk to women worldwide, yet specific role of SERPINA gene family in breast cancer remains unclarified. Data were collected from online databases. SERPINA family gene expression was presented, and prognosis value was evaluated.

A positive TGF-β/miR-9 regulatory loop promotes the expansion and activity of tumour-initiating cells in breast cancer.

Background And Purpose: MicroRNA-9 (miR-9) has previously been described as a dual-functional RNA during breast cancer progression and its roles need to be clarified thoroughly.

Experimental Approach: A miR-9 knockout mode of mouse breast cancer, the MMTV-PyMT model (PyMT-miR-9 ), combined with different human breast cancer cell lines were used to evaluate the effects of miR-9 on breast cancer initiation, progression and metastasis. Lin-NECs (Neoplastic mammary epithelial cells) and pNECs (Pre-neoplastic mammary epithelial cells) were isolated and subjected to tumour-initiation assay.

Emerging Roles of RNF168 in Tumor Progression.

RING finger protein 168 (RNF168) is an E3 ubiquitin ligase with the RING finger domain. It is an important protein contributing to the DNA double-strand damage repair pathway. Recent studies have found that RNF168 is significantly implicated in the occurrence and development of various cancers.

Cold-sensitive ventromedial hypothalamic neurons control homeostatic thermogenesis and social interaction-associated hyperthermia.

Homeostatic thermogenesis is an essential protective feature of endotherms. However, the specific neuronal types involved in cold-induced thermogenesis remain largely unknown. Using functional magnetic resonance imaging and in situ hybridization, we screened for cold-sensitive neurons and found preprodynorphin (PDYN)-expressing cells in the dorsal medial region of the ventromedial hypothalamus (dmVMH) to be a candidate.

Quantitative Relationships Between Individual Lower-Limb Muscle Volumes and Jump and Sprint Performances of Basketball Players.

Xie, T, Crump, KB, Ni, R, Meyer, CH, Hart, JM, Blemker, SS, and Feng, X. Quantitative relationships between individual lower-limb muscle volumes and jump and sprint performances of basketball players. J Strength Cond Res 34(3): 623-631, 2020-Lower body skeletal muscles play an essential role in athletic performance; however, because of the difficulty in obtaining detailed information of each individual muscle, the quantitative relationships between individual muscle volumes and performance are not well studied.

Long-range, high-precision, and high-speed absolute distance measurement based on alternately oscillating optoelectronic oscillators.

We propose an absolute distance measurement method using alternately oscillating optoelectronic oscillators (OEOs) with high speed, high precision, and long range, and describe the dynamic characteristics of the measurement system. Measurement and reference OEOs are oscillated using a 2×2 optical switch, and rough and fine measurements are achieved by low- and high-order-mode oscillation. The distance is determined by the loop length difference between the two OEOs.