Chinese medicine in the treatment of chronic hepatitis B: The mechanisms of signal pathway regulation.

Chronic hepatitis B (CHB) is a chronic inflammatory disease of the liver caused by infection with the hepatitis B virus (HBV), which in later stages can lead to the development of end-stage liver diseases such as cirrhosis and hepatocellular carcinoma in severe cases, jeopardizing long-term quality of life, with a poor prognosis, and placing a serious financial burden on many families around the world. The pathogenesis of the disease is complex and closely related to the immune function of the body, which has not yet been fully elucidated. The development of chronic hepatitis B is closely related to the involvement of various signaling pathways, such as JAK/STAT, PI3K/Akt, Toll-like receptor, NF-κB and MAPK signaling pathways.

Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy.

In recent years, rising living standards and an accelerated lifestyle have led to an increase in the incidence of chronic liver disease. Modern medicine has yet to fully develop effective methods for preventing and treating these conditions due to their complex pathogenesis. Autophagy, a cellular process that maintains homeostasis by removing abnormal proteins, has emerged as a promising therapeutic target for chronic liver diseases.

Atomic-Level Defect Engineering in GeP Nanoflake Biosensors for Gastric Cancer Diagnosis.

Defect engineering offers a promising approach to enhance the sensitivity of biosensing materials by creating abundant chemically active sites. Despite its potential, achieving precise control and modification of these defects remains a significant challenge. Herein, we propose atomic-level defect engineering in GeP two-dimensional (2D) layered materials, following precise growing Au nanoparticles on the single defect active sites for the design of ultrasensitive biosensors.

High-Active Surface of Centimeter-Scale β-InS for Attomolar-Level Hg Sensing.

Recognition layer materials play a crucial role in the functionality of chemical sensors. Although advancements in two-dimensional (2D) materials have promoted sensor development, the controlled fabrication of large-scale recognition layers with highly active sites remains crucial for enhancing sensor sensitivity, especially for trace detection applications. Herein, we propose a strategy for the controlled preparation of centimeter-scale non-layered ultrathin β-InS materials with tailored high-active sites to design ultrasensitive Hg sensors.

Safety and efficacy of percutaneous biopsy and microwave ablation in patients with pulmonary nodules on antithrombotic therapy: A study with rivaroxaban bridging.

Background: To evaluate the safety and efficacy of percutaneous biopsy and microwave ablation (B + MWA) in patients with pulmonary nodules (PNs) who are receiving antithrombotic therapy by rivaroxaban as bridging therapy.

Methods: The study comprised 187 patients with PNs who underwent 187 B + MWA sessions from January 1, 2020, to December 31, 2021. The enrolled patients were divided into two groups: Group A, who received antithrombotic therapy five days before the procedure and received rivaroxaban as a bridging drug during hospitalization, and group B, who had no antithrombotic treatment.

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases.

With the general improvement in living standards in recent years, people's living habits, including their dietary habits, have changed. More people around the world do not follow a healthy diet, leading to an increase in morbidity and even mortality due to digestive system diseases, which shows an increasing trend every year. The advantage of traditional Chinese medicine (TCM) in treating digestive system diseases is evident.

Enhanced Ferromagnetism and Tunable Magnetic Anisotropy in a van der Waals Ferromagnet.

2D van der Waals (vdW) magnets have recently emerged as a promising material system for spintronic device innovations due to their intriguing phenomena in the reduced dimension and simple integration of magnetic heterostructures without the restriction of lattice matching. However, it is still challenging to realize Curie temperature far above room temperature and controllable magnetic anisotropy for spintronics application in 2D vdW magnetic materials. In this work, the pressure-tuned dome-like ferromagnetic-paramagnetic phase diagram in an iron-based 2D layered ferromagnet FeGaTe is reported.

Plasmonic Imaging of Single DNA with Charge Sensitive Monolayer WS.

Imaging the surface charge of biomolecules such as proteins and DNA, is crucial for comprehending their structure and function. Unfortunately, current methods for label-free, sensitive, and rapid imaging of the surface charge of single DNA molecules are limited. Here, we propose a plasmonic microscopy strategy that utilizes charge-sensitive single-crystal monolayer WS materials to image the local charge density of a single λ-DNA molecule.

Ultrasensitive CCL2 Detection in Urine for Diabetic Nephropathy Diagnosis Using a WS-Based Plasmonic Biosensor.

The accurate diagnosis of diabetic nephropathy relies on achieving ultrasensitive biosensing for biomarker detection. However, existing biosensors face challenges such as poor sensitivity, complexity, time-consuming procedures, and high assay costs. To address these limitations, we report a WS-based plasmonic biosensor for the ultrasensitive detection of biomarker candidates in clinical human urine samples associated with diabetic nephropathy.

Ferroelectric BiOTe-Based Plasmonic Biosensor for Ultrasensitive Biomolecular Detection.

Ultrasensitive detection of biomarkers, particularly proteins, and microRNA, is critical for disease early diagnosis. Although surface plasmon resonance biosensors offer label-free, real-time detection, it is challenging to detect biomolecules at low concentrations that only induce a minor mass or refractive index change on the analyte molecules. Here an ultrasensitive plasmonic biosensor strategy is reported by utilizing the ferroelectric properties of BiOTe as a sensitive-layer material.

Interfacial Charge Transfer for Enhancing Nonlinear Saturable Absorption in WS/graphene Heterostructure.

Interlayer charge-transfer (CT) in 2D atomically thin vertical stacks heterostructures offers an unparalleled new approach to regulation of device performance in optoelectronic and photonics applications. Despite the fact that the saturable absorption (SA) in 2D heterostructures involves highly efficient optical modulation in the space and time domain, the lack of explicit SA regulation mechanism at the nanoscale prevents this feature from realizing nanophotonic modulation. Here, the enhancement of SA response via CT in WS/graphene vertical heterostructure is proposed and the related mechanism is demonstrated through simulations and experiments.

Pressure effect on the magnetism and crystal structure of magnetoelectric metal-organic framework [CHNH][Co(HCOO)].

[CHNH][Co(HCOO)] is the first perovskite-like metal-organic framework exhibiting spin-driven magnetoelectric effects. However, the high-pressure tuning effects on the magnetic properties and crystal structure of [CHNH][Co(HCOO)] have not been studied. In this work, alongside ac magnetic susceptibility measurements, we investigate the magnetic transition temperature evolution under high pressure.

An Ultrasensitive SPR biosensor for RNA detection based on robust GeP nanosheets.

Ultrasensitive and rapid detection of biomarkers is among the upmost priorities in promoting healthcare advancements. Improved sensitivity of photonic sensors based on two-dimensional (2D) materials have brought exciting prospects for achieving real-time and label-free biosensing at dilute target concentrations. Here, we report a high-sensitivity surface plasmon resonance (SPR) RNA sensor using metallic 2D GeP nanosheets as the sensing material.

An Ultrasensitive Plasmonic Sensor Based on 2D Ferroelectric Bi O Se.

Plasmonic biosensing is a label-free detection method that is commonly used to measure various biomolecular interactions. However, one of the main challenges in this approach is the ability to detect biomolecules at low concentrations with sufficient sensitivity and detection limits. Here, 2D ferroelectric materials are employed to address the issues with sensitivity in biosensor design.

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review.

Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine. In this review, we summarized the use of network pharmacology technology through studying Chinese medicine single medicine or Chinese medicine compound research ideas and methods for the treatment of ulcerative colitis, based on the application of the current network pharmacology in Chinese medicine research, including the important role in the mechanism of the prediction and verification, to search for new ideas for disease diagnosis and treatment, this study summarizes the application of network pharmacology in the treatment of ulcerative colitis in traditional Chinese medicine, including monotherapy and compound therapy, and considers that relevant research studies have fully demonstrated the function characteristics of the multi-component, multi-target, and multi-pathway of traditional Chinese medicine, and can also explain the connotation of "selecting appropriate treatment methods according to the differences and similarities of pathogenesis" of traditional Chinese medicine. Finally, we raised important questions about the prospects and limitations of network pharmacology, such as differences caused by different data collection methods, a considerable lag, and so on.

Magnetic field reversal of electric polarization and pressure-temperature-magnetic field magnetoelectric phase diagram of the hexaferrite BaSrMgFeO.

Pressure, as an independent thermodynamic parameter, is an effective tool to obtain novel material system and exotic physical phenomena not accessible at ambient conditions, because it profoundly modifies the charge, orbital and spin state by reducing the interatomic distance in crystal structure. However, the studies of magnetoelectricity and multiferroicity are rarely extended to high pressure dimension due to properties measured inside the high pressure vessel being a challenge. Here we reported the temperature-magnetic field-pressure magnetoelectric (ME) phase diagram of Y type hexaferrite BaSrMgFeOderived from static pyroelectric current measurement and dynamic magnetodielectric in diamond anvil cell and piston cylinder cell.

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19.

Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of biological systems, which has become a popular tool in traditional Chinese medicine (TCM) research in recent years. Its characteristics of integrity and systematization provide a new approach for the study on complex TCM systems, which has many similarities with the holistic concept of TCM. It has been widely used to explain the mechanism of TCM treatment of diseases, drug repositioning, and interpretation of compatibility of TCM prescriptions, to promote the modernization of TCM.

Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations.

Ulcerative colitis (UC) is a common clinical inflammatory bowel disease characterized by repeated attacks, difficult treatment, and great harm to the physical and mental health of the patients. The occurrence and development of UC were closely related to the physiological and pathological processes, such as intestinal inflammatory reaction, oxidizing reaction, and immune response. Treatment of ulcerative colitis using Western medicine is often associated with a number of limitations and adverse events.

Pressure Control of the Structure and Multiferroicity in a Hydrogen-Bonded Metal-Organic Framework.

Multiferroic materials with the cross-coupling of magnetic and ferroelectric orders provide a new platform for physics study and designing novel electronic devices. However, the weak coupling strength of ferroelectricity and magnetism is the main obstacle for potential applications. The recent research focuses on enhancing the coupling effect via synthesizing novel materials in a chemical route or tuning the multiferroicity in the physical way.

Advances About Immunoinflammatory Pathogenesis and Treatment in Diabetic Peripheral Neuropathy.

Most diabetic patients develop diabetic peripheral neuropathy (DPN). DPN is related to the increase of inflammatory cells in peripheral nerves, abnormal cytokine expression, oxidative stress, ischemia ,and pro-inflammatory changes in bone marrow. We summarized the progress of immune-inflammatory mechanism and treatment of DPN in recent years.

In Situ Grown Ultrafine RuO Nanoparticles on GeP Nanosheets as the Electrode Material for Flexible Planar Micro-Supercapacitors with High Specific Capacitance and Cyclability.

GeP, as the most representative phosphorus-based material in two-dimensional layered phosphorous compounds, has shown a fairly bright application prospect in the field of energy storage because of its ultrahigh electrical conductivity. However, high-yield exfoliation methods and effective structure construction strategies for GeP nanosheets are still missing, which completely restricts the further application of GeP-based nanocomposites. Here, we not only improved the yield of GeP nanosheets by a liquid nitrogen-assisted liquid-phase exfoliation technique but also constructed the GeP@RuO nanocomposites with the 0D/2D heterostructure by in situ introduction of ultrafine RuO nanoparticles on highly conductive GeP nanosheets using a simple hydrothermal synthesis method, and then applying it to micro-supercapacitors (MSCs) as electrode materials through a mask-assisted vacuum filtration technique.

High-sensitivity and versatile plasmonic biosensor based on grain boundaries in polycrystalline 1L WS films.

Structural defects play an important role in exploitation of two-dimensional layered materials (2DLMs) for advanced biosensors with the increasingly high sensitivity and low detection limit. Grain boundaries (GBs), as an important type of structural defect in polycrystalline 2DLM films, potentially provide sufficient active defect sites for the immobilization of bioreceptor units via chemical functionalization. In this work, we report the selective functionalization of high-density GBs with complementary DNA receptors, via gold nanoparticle (AuNP) linkers, in wafer-scale polycrystalline monolayer (1L) W(Mo)S films as versatile plasmonic biosensing platforms.

Grain-boundary-rich polycrystalline monolayer WS film for attomolar-level Hg sensors.

Emerging two-dimensional (2D) layered materials have been attracting great attention as sensing materials for next-generation high-performance biological and chemical sensors. The sensor performance of 2D materials is strongly dependent on the structural defects as indispensable active sites for analyte adsorption. However, controllable defect engineering in 2D materials is still challenging.

Proximity Enhanced Hydrogen Evolution Reactivity of Substitutional Doped Monolayer WS.

The development of stable and low-cost catalysts with high reactivity to replace Pt-based ones is the central focus but challenging for hydrogen evolution reaction (HER). The incorporation of single atoms into two-dimensional (2D) supports has been demonstrated as an effective strategy because of the highly active single atomic sites and extremely large surface area of two-dimensional materials. However, the doping of single atoms is normally performed on the surface suffering from low stability, especially in acidic media.