Morphological and metabolic changes in Changshan Huyou (Citrus changshan-huyou) following natural tetraploidization.

Background: Polyploids in citrus are generally used to improve crop varieties. Changshan Huyou (Citrus changshan-huyou) is a native citrus species in China that is highly adaptable and has pharmaceutical value. However, the influence in Changshan Huyou following polyploidization remains unclear.

Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.

Background: Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that promotes calcified aortic valve disease (CAVD), but the underlying mechanism remains obscure. Herein, we aim to test the hypothesis that TMAO regulated the inflammatory process in aortic valves via N6-methyladenosine (m6A) RNA methylation-mediated macrophage polarization.

Methods: In vitro, we stimulated macrophages (Phorbol-12-Myristate-13-Acetate-induced THP-1) with TMAO and assessed the expression of methyltransferase-like 3 (Mettl3), IL-1 receptor associated kinase M (IRAK-M) and polarization markers.

The Relationship Between Mental Health Literacy and Social Well-Being: A Longitudinal Study in China.

In this study, 793 college students were examined through the utilization of the socioeconomic status scale, mental health literacy scale, and social well-being questionnaire at T1 and T2, respectively, with the aim of exploring the relationship between mental health literacy and social well-being and the relative static and dynamic development of the two. The results indicated that mental health literacy was significantly and positively correlated with social well-being to a moderate extent (T1: = 0.31; T2: = 0.

PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. The roles of PTEN-induced kinase 1 (PINK1) and peroxiredoxin-2 (Prdx2) in HFpEF pathogenesis remain unclear.

Objective: This study aimed to investigate the interaction between PINK1 and Prdx2 to mitigate cardiac diastolic dysfunction in HFpEF.

Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Study.

Background: Sentinel lymph node biopsy (SLNB) using radioisotope tracer plus blue dye is the gold standard after neoadjuvant chemotherapy (NAC) in initially cN1 breast cancer patients, but clinical use still has limitations. This study aims to examine diagnostic performance of dual indocyanine green (ICG) and methylene blue tracing for SLNB in patients who have completed NAC for breast cancer with initially cN1 disease.

Methods: Adult women (20-80 years of age) scheduled to undergo NAC for biopsy-proven cT0-3N1M0 primary invasive breast cancer were consecutively enrolled in this prospective, multicenter, cohort study.

PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway.

Aims: Sterile inflammation is implicated in the development of heart failure (HF). Mitochondria plays important roles in triggering and maintaining inflammation. Mitophagy is important for regulation of mitochondrial quality and maintenance of cardiac function under pressure overload.

A meta-analysis of conservation tillage management effects on soil organic carbon sequestration and soil greenhouse gas flux.

Conservation tillage practices, including reduced tillage (RT), no-tillage (NT) and straw return (SR), have been widely adopted to enhance soil organic carbon density (PSOC) and improve the soil quality while mitigating the negative environmental impacts of intensive farming. However, current studies on the effects of these practices on SOC sequestration and NO flux show considerable variability, making it challenging to draw definitive conclusions about the individual and combined impacts of conservation tillage practices and introducing substantial uncertainty in estimating the agricultural sector's potential to mitigate climate change. To address this gap, we conducted a meta-analysis of 902 pairwise comparisons from 90 peer-reviewed publications to evaluate the effects of five conservation tillage practices (straw return (SR), reduced tillage (RT), no-tillage (NT), straw return combined with tillage reduction (SR + RT) and straw returning combined with no-tillage (SR + NT)) on C sequestration and NO emissions from agricultural soils.

Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.

Doxorubicin (DOX) is restricted due to its severe cardiotoxicity. There is still a lack of viable and effective drugs to prevent or treat DOX-induced cardiotoxicity(DIC). Vericiguat is widely used to treat heart failure with reduced ejection fraction.

Research progress on the correlation between cataract occurrence and nutrition.

Cataract is a common eye disease characterized by lens opacity, leading to blurred vision and progressive blindness of the eye. Factors affecting the development of cataracts include nutrition, oxidative stress, micronutrients and inflammatory factors, and also include genetics, toxicity, infrared exposure, hyperuricemia, and mechanical injuries. Among the nutritional factors, a balanced diet, vegetarian diet, dairy products and vegetables are protective against cataracts; high-sodium diet, high intake of carbohydrates and polyunsaturated fatty acids may increase the risk of cataracts; and increased intake of proteins, especially animal proteins, may prevent nuclear cataracts.

The Honey Bee Colony's Criterion for Candidate Selection: "Ongoing" or "One-Shot"?

In the honey bee, the queen's death severely threatens the survival of the colony. In an emergency, new queens are reared from young worker larvae, where nepotism is thought to influence the choice of queen candidates by the workers. This article simulates the emergency queen-rearing process in a colony under natural conditions and records the results of colony selection (without nepotism).

Nearly polarization-insensitive angular filters enabled by metal-dielectric photonic crystal in the visible region.

We report on the design and fabrication of nearly polarization-insensitive angular filters, which have been developed through the optimization of one-dimensional / photonic crystals (PCs). We evaluate different initial systems for optimization and compare their results in terms of both the wavelength and angular selectivity. Our findings reveal that relaxing the strict periodic condition of initial photonic crystals with a small number of lattices has enabled improvement in the angular selectivity via Fabry-Perot resonances in dielectric layers, achieving a transmission as high as 81% at normal incidence by optimizing the dielectric layer thickness.

The mechanism of in digesting toxic sugars.

is an economically and medicinally valuable oilseed crop. Honeybee, the most abundant pollinator, rarely visits because of the toxic sugars in the nectar and pollen. These toxic sugars cannot be fully digested by honeybees and inhibit the process of synthesizing trehalose in honeybees.

Occurrence of micropollutants in rural domestic wastewater in Zhejiang Province, China and corresponding wastewater-based epidemiology analysis.

By 2021, rural regions in China were occupied by over 500 million residents, generating an annual volume of 19.5 billion m of rural domestic wastewater (RDW). This study aimed to investigate the occurrence and removal of micropollutants (MPs) in RDW treatment facilities and to perform a corresponding wastewater-based epidemiology analysis (WBE).

Multifunctional Electrostatic Droplet Manipulation on the Femtosecond Laser-Prepared Slippery Surfaces.

A strategy to manipulate droplets on the lubricated slippery surfaces using tribostatic electricity is proposed. By employing femtosecond laser-induced porous microstructures, we prepared a slippery surface with ultralow adhesion to various liquids. Electrostatic induction causes the charges within the droplet to be redistributed; thus, the droplet on the as-prepared slippery surfaces can be guided by electrostatic force under the electrostatic field, with controllable sliding direction and unlimited transport distance.

A root-knot nematode effector targets the Arabidopsis cysteine protease RD21A for degradation to suppress plant defense and promote parasitism.

Meloidogyne incognita is one of the most widely distributed plant-parasitic nematodes and causes severe economic losses annually. The parasite produces effector proteins that play essential roles in successful parasitism. Here, we identified one such effector named MiCE108, which is exclusively expressed within the nematode subventral esophageal gland cells and is upregulated in the early parasitic stage of M.

Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects.

Three genes involved in poly-γ-glutamic acid(γ-PGA)synthesis cloned from Bacillus licheniformis were transformed into cucumber for the first time. Compared with control, its water content increased by 6-14 % and water loss rate decreased by 11-12 %. In zebrafish and human skin experiments, the moisturizing effect of transgenic cucumber was significantly higher than that of CK, γ-PGA and hyaluronic acid group.

A Fused-Ring Electron Acceptor with Phthalimide-Based Ending Groups for Efficient Ternary Organic Solar Cells.

The ternary strategy has been widely applied and recognized to be a valid strategy to enhance the organic photovoltaics' (OPVs) performance. Here, a new fused-ring electron acceptor, BTP-PIO, is designed and synthesized, whose ending groups were replaced by a phthalimide-based group (2-butylcyclopenta[]isoindole-1,3,5,7(2,6)-tetraone) from traditional 2-(3-oxo-2,3-dihydro-1-inden-1-ylidene)malononitrile. The phthalimide-based ending groups endow BTP-PIO with the highest lowest unoccupied molecular orbital (LUMO) level and wider band gap than those of Y6.

A viologen-derived luminescent material exhibiting photochromism, photocontrolled luminescence and selective detection of CrO in aqueous solution.

Stable viologen-derived multifunctional smart materials exhibit widespread practical applications in many areas. In this study, a viologen-derived material with 4-fold interpenetrating diamondoid network, {[Cd(1,4-ndc)(cpbpy)]·2HO}, was successfully constructed based on asymmetrical N-(3-carboxyphenyl)-4,4'-bipyridinium (cpbpy) and 1,4-naphthalenedicarboxylic acid (1,4-Hndc). The compound shows reversible photochromic behavior under a xenon lamp, which are proved by UV-vis spectra and EPR characterizations.

Effect of Streptomyces JD211 application on soil physicochemical properties and NO emission characteristics of rice rhizosphere.

Biocontrol agent, as a pollution-free and sustainable plant disease control method, can inhibit the spread of soil-borne diseases and promote the growth of crops. However, there are few studies on the effect of biocontrol agent on NO emission in rice soil. In this study, after the application of the biocontrol agent Streptomyces JD211, NO emission from rice soil were measured, and the relationship between the agent and soil NO emissions were studied in soil chemistry and molecular biology.

Review of casualties and losses of UK fishing vessels from 2013 to 2020.

This study analyses the relationship between vessel groups (small, medium and large) and casualty or loss type of UK fishing vehicles based on a summary of information concerning casualties and losses that occurred on fishing vessels in the UK from 2013 to 2020. The study establishes loss of control as the main cause of casualty occurrences for all fishing vessels. Further, flooding/foundering is the main contributor to the loss of fishing vessels smaller than 24 m in length, and grounding/stranding is the main contributor to the loss of fishing vessels 24 m or longer.

Response of Wheat, Maize, and Rice to Changes in Temperature, Precipitation, CO Concentration, and Uncertainty Based on Crop Simulation Approaches.

The influence of global climate change on agricultural productivity is an essential issue of ongoing concern. The growth and development of wheat, maize, and rice are influenced by elevated atmospheric CO concentrations, increased temperatures, and seasonal rainfall patterns. However, due to differences in research methodologies (e.

Prognostic Value of Systemic Inflammation Response Index in Acute Type A Aortic Dissection.

Background: The study aimed to evaluate the prognostic value of preoperative systemic inflammation response index (SIRI) for acute type A aortic dissection (ATAD) following open surgery.

Methods And Results: Totally, 410 ATAD patients underwent open surgery from 2019 to 2021 were enrolled in the study. Among the patients, the in-hospital mortality was 14.

Soluble perinone isomers as electron transport materials for p-i-n perovskite solar cells.

We synthesized three soluble perinone isomers as electron transport materials in p-i-n perovskite solar cells. The -isomer BBIN-2 possesses higher LUMO level and electron mobility than the -isomers. The BBIN-2 devices showed the highest power conversion efficiency of 19.