IConDiffNet: an unsupervised inverse-consistent diffeomorphic network for medical image registration.

This paper introduces a novel unsupervised inverse-consistent diffeomorphic registration network termed IConDiffNet, which incorporates an energy constraint that minimizes the total energy expended during the deformation process. The IConDiffNet architecture consists of two symmetric paths, each employing multiple recursive cascaded updating blocks (neural networks) to handle different virtual time steps parameterizing the path from the initial undeformed image to the final deformation. These blocks estimate velocities corresponding to specific time steps, generating a series of smooth time-dependent velocity vector fields.

Methane degassing in global river reservoirs and its impacts on carbon budgets and sustainable water management.

Degassing methane (CH) through reservoir water compromises hydroelectricity's presumed low-carbon status, which has emerged as a critical hotspot for global carbon dynamics. However, a comprehensive understanding of the involved pathways remains elusive, hindering the accurate estimation of global reservoirs' carbon budget (emission-to-burial ratio). This study presents a holistic upscaling approach to assess methane degassing in global river reservoirs and its impacts on carbon budgets.

Clinical strategy study on prenatal screening and diagnostic model for Down syndrome.

Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local or geographically proximate provinces and lacked universality and representativeness.

Variability in NO emission controls among different ponds within a hilly watershed.

While it is well established that small water bodies like ponds play a disproportionately large role in contributing to NO emissions, few studies have focused on lowland ponds in hilly watersheds. Here, we explored the characteristics of NO concentrations and emissions from various typical ponds (village, tea, forested, and aquaculture ponds) in a hilly watershed and examined the specific controls influencing NO production. Our findings revealed that tea ponds exhibited the highest NO flux (8.

Predicting the recurrence of spontaneous intracerebral hemorrhage using a machine learning model.

Background: Recurrence can worsen conditions and increase mortality in ICH patients. Predicting the recurrence risk and preventing or treating these patients is a rational strategy to improve outcomes potentially. A machine learning model with improved performance is necessary to predict recurrence.

The white lupin trehalase gene LaTRE1 regulates cluster root formation and function under phosphorus deficiency.

Under phosphorus (P) deficiency, white lupin (Lupinus albus L.) forms a specialized root structure, called cluster root (CR), to improve soil exploration and nutrient acquisition. Sugar signaling is thought to play a vital role in the development of CR.

SnO Interacted with Sodium Thiosulfate for Perovskite Solar Cells over 25% Efficiency.

Tin oxide (SnO) as electron transportation layer (ETL) has demonstrated remarkable performance applied in perovskite solar cells but still accommodated a host of defects such as oxygen vacancies, uncoordinated Sn , and absorbed hydroxyl groups. Here, we use inorganic sodium thiosulfate NaSO to modify SnO nanoparticles in a bulk blending manner. Strong interaction between NaSO and SnO occurs, as reflected from the elemental chemical state change.

Unsupervised Machine Learning Revealed that Repeat Transcranial Magnetic Stimulation is More Suitable for Stroke Patients with Statin.

Introduction: Repeat transcranial magnetic stimulation (rTMS) demonstrates beneficial effects for stroke patients, though its efficacy varies due to the complexity of patient conditions and disease progression. Unsupervised machine learning could be the optimal solution for identifying target patients for transcranial magnetic stimulation treatment.

Methods: We collected data from ischaemic stroke patients treated with rTMS.

Sensitive electrochemical flow injection analysis of HO released from cells with a pass-through mode.

Conventional plate electrodes were commonly used in electrochemical flow injection analysis and only part of molecules diffused to the plane of electrodes could be detected, which would limit the performance of electrochemical detection. In this study, a low-cost native stainless steel wire mesh (SSWM) electrode was integrated into a 3D-printed device for electrochemical flow injection analysis with a pass-through mode, which is different compared with previous flow-through mode. This strategy was applied for sensitive analysis of hydrogen peroxide (HO) released from cells.

The greener the living environment, the better the health? Examining the effects of multiple green exposure metrics on physical activity and health among young students.

The sedentary and less active lifestyle of modern college students has a significant impact on the physical and mental well-being of the college community. Campus Green Spaces (GSs) are crucial in promoting physical activity and improving students' health. However, previous research has focused on evaluating campuses as a whole, without considering the diverse spatial scenarios within the campus environment.

Identification of copy number variations among fetuses with isolated ultrasound soft markers in pregnant women not of advanced maternal age.

Background: Pathogenic (P) copy number variants (CNVs) may be associated with second-trimester ultrasound soft markers (USMs), and noninvasive prenatal screening (NIPS) can enable interrogate the entire fetal genome to screening of fetal CNVs. This study evaluated the clinical application of NIPS for detecting CNVs among fetuses with USMs in pregnant women not of advanced maternal age (AMA).

Results: Fetal aneuploidies and CNVs were identified in 6647 pregnant women using the Berry Genomics NIPS algorithm.

Risk factors for major adverse cardiovascular events after coronary artery bypass grafting using radial artery grafts.

Background: Coronary artery bypass grafting using radial artery grafts (RA-CABG) has improved long-term outcomes. However, major adverse cardiovascular events (MACE-4, including all-cause death, myocardial infarction, stroke, and repeat revascularization) after RA-CABG still occur and the predictors remain uncertain. This study aimed to detect independent risk factors of MACE-4 after RA-CABG.

Boosting Bifunctional Catalysis by Integrating Active Faceted Intermetallic Nanocrystals and Strained Pt-Ir Functional Shells.

PtIr-based nanostructures are fascinating materials for application in bifunctional oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalysis. However, the fabrication of PtIr nanocatalysts with clear geometric features and structural configurations, which are crucial for enhancing the bifunctionality, remains challenging. Herein, PtCo@PtIr nanoparticles are precisely designed and fabricated with a quasi-octahedral PtCo nanocrystal as a highly atomically ordered core and an ultrathin PtIr atomic layer as a compressively strained shell.

Maternal, neonatal, pregnancy outcome characteristics of pregnant women with high plasma cell-free DNA concentration in non-invasive prenatal screening: a retrospective analysis.

Objective: Cell-free DNA (cfDNA) is a useful biomarker in various clinical contexts. Herein, we aimed to identify maternal characteristics and pregnancy outcomes associated with a failed NIPS test due to high cfDNA concentrations.

Methods: A retrospective study of cases with high plasma cfDNA concentration in pregnant women in which NIPS test was performed (from 174,318 cases).

Observations of a black hole x-ray binary indicate formation of a magnetically arrested disk.

Accretion of material onto a black hole drags any magnetic fields present inwards, increasing their strength. Theory predicts that sufficiently strong magnetic fields can halt the accretion flow, producing a magnetically arrested disk (MAD). We analyzed archival multiwavelength observations of an outburst from the black hole x-ray binary MAXI J1820+070 in 2018.

Adaptation of high-efficiency CRISPR/Cas9-based multiplex genome editing system in white lupin by using endogenous promoters.

White lupin (Lupinus albus L.) is an important crop with high phosphorus (P) use efficiency; however, technologies for its functional genomic and molecular analyses are limited. Cluster regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system has been applied to gene editing and function genomics in many crops, but its application in white lupin has not been well documented.

Maternal and fetal factors influencing fetal fraction: A retrospective analysis of 153,306 pregnant women undergoing noninvasive prenatal screening.

Background: Genetic factors are important causes of birth defects. Noninvasive prenatal screening (NIPS) is widely used for prenatal screening of trisomy 21, trisomy 18, and trisomy 13, which are the three most common fetal aneuploidies. Fetal fraction refers to the proportion of cell-free fetal DNA in maternal plasma, which can influence the accuracy of NIPS.

Tuning Carbon Defect in Copper Single-Atom Catalysts for Efficient Oxygen Reduction.

Defect chemistry in carbon matrix shows great potential for promoting the oxygen reduction reaction (ORR) of metal single-atom catalysts. Herein, a modified pyrolysis strategy is proposed to tune carbon defects in copper single-atom catalysts (Cu-SACs) to fully understand their positive effect on the ORR activity. The optimized Cu-SACs with controllable carbon defect degree and enhanced active specific surface area can exhibit improved ORR activity with a half-wave potential of 0.

MoS/NiSe/rGO Multiple-Interfaced Sandwich-like Nanostructures as Efficient Electrocatalysts for Overall Water Splitting.

Constructing a heterogeneous interface using different components is one of the effective measures to achieve the bifunctionality of nanocatalysts, while synergistic interactions between multiple interfaces can further optimize the performance of single-interface nanocatalysts. The non-precious metal nanocatalysts MoS/NiSe/reduced graphene oxide (rGO) bilayer sandwich-like nanostructure with multiple well-defined interfaces is prepared by a simple hydrothermal method. MoS and rGO are layered nanostructures with clear boundaries, and the NiSe nanoparticles with uniform size are sandwiched between both layered nanostructures.

Mixed-Dimensional Pt-Ni Alloy Polyhedral Nanochains as Bifunctional Electrocatalysts for Direct Methanol Fuel Cells.

Pt nanocatalysts play a critical role in direct methanol fuel cells (DMFCs) due to their appropriate adsorption/desorption energy, yet suffer from an unbalanced relationship between size-dependent activity and stability. Herein, mixed-dimensional Pt-Ni alloy polyhedral nanochains (Pt-Ni PNCs) with an ordered assembly of a nanopolyhedra-nanowire-nanopolyhedra architecture are fabricated as bifunctional electrocatalysts for DMFCs, effectively alleviating the size effect. The Pt-Ni PNCs exhibit 7.

MNSs-mediated N-glycan processing is essential for auxin homeostasis in roots during alkaline response.

Early steps in the endoplasmic reticulum (ER) lumen and -Golgi comprise trimming of N-glycans by class I α-mannosidases (MNSs) play crucial roles in root growth and stress response. Herein, we found that the root growth inhibition in the mutant was partially rescued under alkaline condition, and inhibitor treatment to disrupt auxin transport counteracted this alkaline-maintained root growth. Further study showed that indole-3-acetic acid (IAA) levels were undetectable in at normal condition and recovered at alkaline condition, which corroborate our N-glycopeptide profiling, from which N-glycopeptides related with IAA biosynthesis, amino acid conjugates hydrolysis, and response showed differential abundance between normal and alkaline conditions in .