Methods of Manipulation of Acoustic Radiation Using Metamaterials with a Focus on Polymers: Design and Mechanism Insights.

The manipulation of acoustic waves is becoming increasingly crucial in research and practical applications. The coordinate transformation methods and acoustic metamaterials represent two significant areas of study that offer innovative strategies for precise acoustic wave control. This review highlights the applications of these methods in acoustic wave manipulation and examines their synergistic effects.

Navigating first-line therapies for extensive-stage small-cell lung cancer: a frequentist network meta-analysis and systematic review.

To identify the optimal first-line treatment for patients with extensive-stage small-cell lung cancer (ES-SCLC). We conducted a network meta-analysis (CRD42023486863) to systematically evaluate the efficacy and safety of eight first-line treatment regimens for ES-SCLC, including 15 clinical trials. Our analysis showed that the PD-1/PD-L1 + etoposide combined with platinum (EP) and PD-L1 + vascular endothelial growth factor (VEGF) + EP regimens significantly enhanced overall survival and progression-free survival, with subgroup analysis revealing that serplulimab ranked as the most promising option for improving overall survival.

mutation landscape in non-small cell lung cancer patients in Northeast China.

Objective: This study aimed to explore erb-b2 receptor tyrosine kinase 2 () gene mutations in patients with non-small cell lung cancers (NSCLC) in Northeast China, and to analyze mutation subtypes and clinicopathological characteristics related to the presence of mutations.

Methods: In this study, 1087 tissue samples, 368 whole blood samples, and 68 pleural effusion samples from 1349 NSCLC were collected. Next-generation sequencing (NGS) was used to perform genetic testing on the samples.

Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.

Objectives: In this study, we sought to evaluate purpurin, a natural biomedicine and a potential inhibitor in decreasing the growth rate of lung cancer cells by modulating the role of PI3K/AKT signalling-associated proliferation and apoptosis.

Methods: A549 cells were treated with purpurin (30 μM) for 24 and 48 h incubation, respectively, and it has been analysed for cytotoxicity, ROS-mediated apoptotic staining. Moreover, purpurin-mediated lipid peroxidation and GSH were measured by biochemical estimation.