Expanding the UTAUT2 framework to determine the drivers of mobile shopping behaviour among older adults.

In the current severe aging of the population, the problem of "digital divide" of the elderly has become increasingly prominent, and the elderly market represents a vast demographic that is increasingly becoming an important customer segment for mobile shopping in the future. However, there is currently insufficient attention given to the research on mobile shopping behavior among older adults. This study tries to answer what are the driving factors of mobile phone shopping behavior among the elderly? The purpose of this study is to analyze the factors that drive the elderly's mobile phone shopping behavior, and to establish a mobile phone shopping acceptance model for the elderly to predict the factors of the elderly's behavioral intention of using smart phones.

Factors affecting students' online courses learning behaviors.

Online course learning is an important part of higher education curriculum. However, the factors influencing college students' online course learning behavior are poorly understood. The purpose of this study is to analyze the factors affecting college students' online course learning behavior.

Psychological factors affecting potential users' intention to use autonomous vehicles.

As a currently emerging technology and an emerging intelligent mode of transport, autonomous vehicles (AVs) with lots of potential advantages need attention in terms of acceptability of their users. This research incorporates three psychological factors of perceived trust, perceived value, and perceived enjoyment into the technology acceptance model, and explores the influence of these factors on the potential use intention of AVs users. In this study, the questionnaire data from 232 participants were analysed, and the structural equation model test study model was adopted, and nine hypotheses proposed in this study were verified.

Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning.

Cytochrome P450 17A1 (CYP17A1) is one of the key enzymes in steroidogenesis that produces dehydroepiandrosterone (DHEA) from cholesterol. Abnormal DHEA production may lead to the progression of severe diseases, such as prostatic and breast cancers. Thus, CYP17A1 is a druggable target for anti-cancer molecule development.

Camellia oil ( Abel.) treatment improves high-fat diet-induced atherosclerosis in apolipoprotein E (ApoE) mice.

Atherosclerosis is the main cause of cardiovascular diseases, and healthy dietary habits are a feasible strategy to prevent atherosclerosis development. Camellia oil, an edible plant oil, exhibits multiple beneficial cardiovascular effects. Our previous study showed that oral administration of camellia oil attenuated hyperglycemia, fat deposits in the liver, and the atherosclerosis index in high-fat diet (HFD)-induced obese mice.

On the force field optimisation of [Formula: see text]-lactam cores using the force field Toolkit.

When employing molecular dynamics (MD) simulations for computer-aided drug design, the quality of the used force fields is highly important. Here we present reparametrisations of the force fields for the core molecules from 9 different [Formula: see text]-lactam classes, for which we utilized the force field Toolkit and Gaussian calculations. We focus on the parametrisation of the dihedral angles, with the goal of reproducing the optimised quantum geometry in MD simulations.

Research on the use intention of potential designers of unmanned cars based on technology acceptance model.

The success of unmanned car, an emerging tool of transportation with so many advantages, depends to a large extent on its user acceptability. Potential designers are both the decision makers of driverless car design and the users of driverless cars. This study aims to explore the influencing factors of the potential designers' intention to use unmanned cars.

Oral administration of camellia oil ameliorates obesity and modifies the gut microbiota composition in mice fed a high-fat diet.

Obesity, which is often caused by adipocyte metabolism dysfunction, is rapidly becoming a serious global health issue. Studies in the literature have shown that camellia oil (Camellia oleifera Abel) exerted potential lipid regulation and other multiple biological activities. Here, we aimed to investigate the effects of camellia oil on obese mice induced by a high-fat diet and to explore gut microbiota alterations after camellia oil intervention.

Attitudes of the elderly living independently towards the use of robots to assist with activities of daily living.

Background: Robots are gaining attention as a potential solution to aging.

Objective: The purpose of this study is to explore the attitude of robot assistance in Activities of Daily Living (ADLs) among elderly people living independently.

Methods: The one-on-one interview, buddy robot video and questionnaire survey were used to analyze mean, median, range, and the test results of non-parametric statistical methods such as Wilcoxon sign-rank test statistic and one-sample Wilcoxon sign-rank test statistic, so as to explore the attitude of the elderly living independently towards robot-assisted ADLs and the acceptance of the use of robots in 32 ADLs.

β-Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline-deficient diet in mice.

Nonalcoholic steatohepatitis (NASH) is becoming a huge global health problem. Studies showed that β-glucan displayed potent anti-inflammatory and other multi-beneficial pharmacological properties. Thus, the objective of this study was to investigate the effects of β-glucan on NASH mice induced by the MCD diet.

Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature.

Cardiotoxicity is a well-known adverse effect of doxorubicin (Dox) administration, but the underlying molecular mechanism of this effect is not fully understood. Over the past two decades, considerable efforts have focused on the potential molecular targets of cardiotoxicity in the hope that novel targeted therapies will be generated to attenuate Dox-induced cardiotoxicity. Here, we provide a comprehensive overview of genetically modified animals that show enhanced or reduced susceptibility to the cardiotoxic effects of Dox.