Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.

Traumatic brain injury (TBI) is a predominant cause of long-term disability in adults, yet the molecular mechanisms underpinning the neuropathological processes associated with it remain inadequately understood. Neutrophil cytosolic factor 1 (NCF1, also known as p47) is one of the cytosolic components of NADPH oxidase NOX2. In this study, we observed a reduction in the volume of TBI-induced brain lesions in NCF1-knockout mice compared to controls.

Ultrasensitive Surface-Enhanced Raman Scattering Platform for Protein Detection via Active Delivery to Nanogaps as a Hotspot.

Surface-enhanced Raman scattering (SERS) is an attractive technique in molecular detection with high sensitivity and label-free characteristics. However, its use in protein detection is limited by the large volume of proteins, hindering its approach to the narrow spaces of hotspots. In this study, we fabricated a Au nanoTriangle plate Array on Gel (AuTAG) as an SERS substrate by attaching a Au nanoTriangle plate (AuNT) arrangement on a thermoresponsive hydrogel surface.

Synthesis and Aggregation Behavior of Hexameric Quaternary Ammonium Salt Surfactant Tz-6CQC.

A hexameric quaternary ammonium salt surfactant Tz-6CQC featuring a rigid triazine spacer and six ammonium groups was synthesized. The molecular structure and aggregation behavior of Tz-6CQC were characterized by nuclear magnetic resonance spectroscopy, surface tension, conductivity, dynamic light scattering, and transmission electron microscopy, etc. Dissipative particle dynamics (DPD) simulation was employed to investigate the self-assembly behavior of Tz-6CQC at different concentrations.

Synthesis and Aggregation Behavior of Jellyfish-Shaped Triazine Hexamer Quaternary Ammonium Chloride Surfactant.

A novel jellyfish-shaped triazine hexamer quaternary ammonium chloride surfactant (THQC) was synthesized, which consisted of one triazine spacer group and six long flexible hydrophobic chains. The molecular structure and aggregation behavior of THQC was investigated by nuclear magnetic resonance (NMR), surface tension, electrical conductivity, dynamic light scattering (DLS), transmission electron microscope (TEM), etc. The results show that the jellyfish-shaped THQC has better surface activity and lower surface tension than traditional ionic and Gemini surfactants in aqueous solution.