Preventive intervention with Agaricus blazei murill polysaccharide exerts anti-tumor immune effect on intraperitoneal metastasis colorectal cancer.

Agaricus blazei murill (ABM) mainly exerts its antitumor effect via modulation of the immune system. However, the immunomodulatory role of the ABM polysaccharide (ABMP) in mice with subcutaneously and intraperitoneally implanted MC38 tumor remains to be explored. This study aimed to define the progression effect of inhibiting tumor of ABMP in subcutaneous and intraperitoneal models and its effect on tumor microenvironment (TME) metabolism.

Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system.

The potential antitumor function of polysaccharides is well accepted, it is unclear whether polysaccharides have immunoregulatory effect on CD8 T lymphocyte cells to attack tumor cells. To evaluate the CD8 T function enhancing role of polysaccharide compounds, the MC38-N4/OT-I co-culture system was established. The synergistic and complementary immune effect of α-glucopyranose-rich compound polysaccharides can be achieved by manipulating the antigen-specific T-cell expansion capacity and efficacy.

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

Scope: Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.

Methods And Results: Water extract produces a G.

Fe doped NiP nanosheet arrays with rich P vacancies via phase transformation for efficient overall water splitting.

Proper vacancy engineering is considered as a promising strategy to improve intrinsic activity, but it is challenging to construct rich vacancies by a simple strategy. Herein, Fe doped NiP nanosheet arrays with rich P vacancies are developed via a facile phase transformation strategy. Based on systematic investigations, we have demonstrated that an optimized surface electronic structure, abundant active sites and improved charge transport capability can be effectively achieved by vacancy engineering.

Rich P vacancies modulate NiP/CuP interfaced nanosheets for electrocatalytic alkaline water splitting.

Constructing well-defined interfaces is vital to improve the electrocatalytic properties, but the studies on transition-metal-interface electrocatalysts with rich vacancies are rarely reported. Here, rich P vacancies to modulate NiP/CuP interfaced nanosheets for overall water splitting is demonstrated. We conduct a series of experimental parameters to adjust the nanostructures of NiP/CuP, and to get insight into the synergistic effects of interfaces and P vacancies on the catalytic activities.

Free-standing porous NiP-NiP heterostructured arrays for efficient electrocatalytic water splitting.

Constructing heterointerfaces in heterostructures could effectively enlarge the electroactive sites and enhance the interfacial charge transfer, and thus improve the electrocatalytic performances. Herein, free-standing porous NiP-NiP heterostructured arrays are successfully prepared through in situ phosphating Ni(OH) arrays by simply tuning the reaction temperatures. Contributing from the interfacial coupling effects of two phases, large surface areas, highly conductive support of carbon cloth substrates and unique free-standing arrays, NiP-NiP heterostructured arrays show the enhanced kinetics and electrocatalytic performances for the hydrogen evolution reaction, oxygen evolution reaction and overall water splitting.