Publications by authors named "Tianxing Ying"
Anaplastic thyroid cancer (ATC) is a rare but fatal cancer with BRAF mutation ranging from 30 to 50%. Histone lysine lactylation represents a novel epigenetic mark that translates cellular metabolic signals into transcriptional regulation. It is not clear whether the Warburg effect can promote the proliferation of ATC with BRAFV600E mutation via metabolite-mediated histone lactylation.
View Article and Find Full Text PDFMost papillary thyroid carcinomas (PTCs) can be diagnosed preoperatively by routine evaluation, such as thyroid ultrasonography and fine-needle aspiration biopsy. Nevertheless, understanding how to differentiate indolent thyroid tumors from aggressive thyroid cancers remains a challenge, which may cause overtreatment. This study aimed to identify papillary thyroid cancer-specific indicators with whole-genome DNA methylation and gene expression profiles utilizing Infinium Methylation EPIC BeadChip (850k) and RNA arrays.
View Article and Find Full Text PDFThe diagnosis of follicular thyroid carcinoma (FTC) prior surgical resection remains a challenge, as routine screening methods, such as ultrasound or even FNAB, could not diagnose FTC preoperatively. Here, we performed an integrative analysis of DNA methylation and RNA array data from our own cohort (14 Follicular thyroid carcinoma vs 16 Benign thyroid lesion) to identify thyroid cancer-specific DNA methylation markers. We first identified differentially methylated and expressed genes and examined their correlations.
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- Chronic exposure to low-dose cadmium (Cd) is linked to the development of nonalcoholic steatohepatitis (NASH) in mice, causing increased fat deposition, hepatocyte destruction, and inflammation in the liver.
- The study introduced a murine model, where drinking water with Cd significantly affected liver health over 6 to 12 weeks, supporting the idea that Cd can promote NASH.
- The research also found that Cd disrupts fatty acid metabolism, particularly by inhibiting the desaturation process, leading to toxic saturated fatty acids that worsen liver damage and inflammation.