Clinical value of fractional flow reserve in coronary heart disease: A retrospective study.

This study investigated the clinical value of coronary arteriography (CAG) combined with fractional flow reserve (FFR) in the treatment of coronary heart disease (CHD) with coronary artery stenosis exceeding 70%. A retrospective analysis was conducted on 344 patients with CHD treated at the Gansu Institute of Cardiovascular Science from January 2020 to May 2022. The patients were divided into the CAG group (n = 138) and the CAG + FFR group (n = 206).

Four case reports of left anterior descending restenosis treated via the internal mammary artery: A literature review.

Objective: To analyse four cases of intervention via the internal mammary artery-anterior descending branch and provide and summarise the clinical treatment experience.

Methods: The clinical data of four patients with distal restenosis of a left anterior descending artery (LAD) anastomosis after left internal mammary artery (LIMA)-LAD bypass surgery, who were admitted to the Gansu Institute of Cardiovascular Diseases between March 2013 and April 2022, were retrospectively analysed and reviewed together with the relevant literature.

Results: Among the four patients, one was treated with intracoronary stenting via the internal mammary artery route, two were treated with intracoronary drug-coated balloon dilation (one of whom underwent fractional flow reserve [FFR] testing), and two underwent FFR testing (one of whom had a negative test result until the end of the procedure and continued to take medication during follow-up; the other patient had a positive result and further interventions).

Fractional flow reserve measured left internal mammary artery after coronary artery bypass grafting: Two case reports.

Background: The fractional flow reserve (FFR) has made the treatment of coronary heart disease more precise. However, there are few reports on the measurement of FFR the left internal mammary artery (LIMA). Herein, we described the determination of further treatments by measuring FFR the LIMA in 2 cases after coronary artery bypass grafting (CABG).

Advances in Drug Discovery Targeting Lysosomal Membrane Proteins.

Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases.

Modeling of Rapid Pam Systems Based on Electrothermal Micromirror for High-Resolution Facial Angiography.

In this paper, a portable photoacoustic microscopy (PAM) system is proposed based on a large stroke electrothermal micromirror to achieve high resolution and fast imaging. The crucial micromirror in the system realizes a precise and efficient 2-axis control. Two different designs of electrothermal actuators with "O" and "Z" shape are evenly located around the four directions of mirror plate.

Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells.

Cardiovascular diseases (CVDs) are a major cause of mortality around the world, and the presence of atherosclerosis is the most common characteristic in patients with CVDs. Cysteine‑rich angiogenic inducer 61 (CCN1) has been reported to serve an important role in the pathogenesis of atherosclerotic lesions. The aim of the present study was to investigate whether CCN1 could regulate the inflammation and apoptosis of endothelial cells induced by palmitic acid (PA).

Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell.

Tumor necrosis factor-α (TNF-α) promotes monocyte adhesion to endothelium and accumulation of endothelium will lead to atherosclerosis. The present study explored Angiopoietin-like protein (Angptl7) as a potential target in the process of atherosclerosis, and its role in the adhesion and oxidative stress induced by TNF-α in human umbilical vein epithelial cells (HUVEC). The initiation of atherosclerosis is endothelial injury.

Chain Extension and Synergistic Flame-Retardant Effect of Aromatic Schiff Base Diepoxide on Polyamide 6/Aluminum Diethylphosphinate Composites.

A way to suppress the deterioration in mechanical properties of polyamide 6 (PA6) is required, especially with high loading of flame retardants in the matrix. In this study, a novel aromatic Schiff base diepoxide (DES) was synthesized. It exhibited an efficient chain extension effect on PA6 and a synergistic flame-retardant effect with aluminum diethylphosphinate (AlPi) for PA6.

Unravelling the Self-Assembly of Diketopyrrolopyrrole-Based Photovoltaic Molecules.

The nanostructure of bulk heterojunction in an organic solar cell dominating the electron transport process plays an important role in improving the device efficiency. However, there is still a great need for further understanding the local nanostructures from the viewpoint of molecular design because of the complex alignment in the solid film. In this work, four kinds of photovoltaic materials containing a diketopyrrolopyrrole (DPP) unit combined with other different building blocks were selected and their self-assembled structures on a solid surface were studied by scanning tunneling microscopy technique in combination with theory calculations.

The curative effect of synthetic treatment for refractory acute myocardial infarction.

Background: This study aims to investigate the curative effect of synthetic treatment for refractory acute myocardial infarction (AMI).

Methods: A total of 76 patients with coronary AMI accompanied by shock, who were treated with combined therapy from August 1999 to April 2017, were included into this study. Sixty patients received emergency percutaneous coronary intervention (PCI).

Dimeric Porphyrin Small Molecules for Efficient Organic Solar Cells with High Photoelectron Response in the Near-Infrared Region.

Small molecules (SMs) with elongated backbones are promising for achieving a higher photovoltaic performance. Herein, a dimeric porphyrin small molecule, ZnP2-DPP, consisting of two porphyrin units linked with an ethynylene as the core and two diketopyrrolopyrrole (DPP) units as the arms is designed and synthesized as an electron donor for solution-processed bulk-heterojunction (BHJ) organic solar cells (OSCs). A significantly enhanced power conversion efficiency of 8.

Ternary Solar Cells Based on Two Small Molecule Donors with Same Conjugated Backbone: The Role of Good Miscibility and Hole Relay Process.

Ternary organic solar cells (OSCs) are very attractive for further enhancing the power conversion efficiencies (PCEs) of binary ones but still with a single active layer. However, improving the PCEs is still challenging because a ternary cell with one more component is more complicated on phase separation behavior. If the two donors or two acceptors have similar chemical structures, good miscibility can be expected to reduce the try-and-error work.

Conjugated D-A porphyrin dimers for solution-processed bulk-heterojunction organic solar cells.

Three conjugated D-A porphyrin dimers (DPP-ZnP-E)2, (DPP-ZnP-E)2-2T and (DPP-ZnP-E)2-Ph linked with diethynylene, diethynylene-dithiophene and diethynylene-phenylene have been developed for bulk heterojunction solar cells with high power conversion efficiencies of 4.50%, 5.50% and 6.

Modifying the Chemical Structure of a Porphyrin Small Molecule with Benzothiophene Groups for the Reproducible Fabrication of High Performance Solar Cells.

A porphyrin-based molecule DPPEZnP-BzTBO with bulky benzothiophene groups was designed and synthesized as an electron donor material for bulk heterojunction (BHJ) solar cells. The optimized devices under thermal annealing (TA) and then chloroform solvent vapor anneanling (SVA) for 80 s exhibited an outstanding power conversion efficiencie (PCE) of 9.08%.

Multi-Length-Scale Morphologies Driven by Mixed Additives in Porphyrin-Based Organic Photovoltaics.

A new category of deep-absorbing small molecules is developed. Optimized devices driven by mixed additives show a remarkable short-circuit current of ≈20 mA cm(-2) and a highest power conversion efficiency of 9.06%.

CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth.

Our previous studies have suggested that harboring a soluble coxsackie-adenovirus receptor-ligand (sCAR-ligand) fusion protein expression cassette in the viral genome may provide a universal method to redirect oncolytic adenoviruses to various membrane receptors on cancer cells resisting to serotype 5 adenovirus infection. We report here a novel oncolytic adenovirus vector redirected to CD47+ leukemia cells though carrying a sCAR-4N1 expression cassette in the viral genome, forming Ad.4N1, in which 4N1 represents the C-terminal CD47-binding domain of thrombospondin-1.