Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.

Abnormal microglia activation causes sever neuroinflammation, contributing to the development of many diseases, yet the mechanism remains incompletely unknown. In current study, we identified that Hydroxysafflor yellow A (HYA), a chalcone glycoside derived from effectively attenuates LPS-induced inflammation response in primary microglia regulating the expression of inflammatory genes and remodeling the polarization of microglia. We also reported the effects of HYA on improving lipopolysaccharide (LPS)-stimulated mitochondrial dysfunction and oxidative stress for the first time.

[Effect of "Yinqi Guiyuan" needling on primary insomnia].

Objective: To observe the clinical effect of "Yinqi Guiyuan" needling in the treatment of primary insomnia.

Methods: A total of 79 primary insomnia outpatients were randomly divided into treatment group (=40) and control group (=39). The patients in the control group were given oral Estazolam tablets once a day, for successive 4 weeks.