Publications by authors named "Tianxi Shen"

Article Synopsis
  • - The study investigates how chiral tetrapeptide (Ac-FFFK-OH, or FFFK) supramolecular polymers can modulate the immune response, specifically targeting macrophage polarization to enhance tissue repair and regeneration.
  • - Findings reveal that chiral FFFK nanofibers promote M2 macrophage polarization by activating the Src-STAT6 signaling pathway, which is critical for restoring tissue homeostasis after injury.
  • - The research highlights that L-chirality of the FFFK peptide is more effective than D-chirality in maintaining M2 polarization, suggesting a novel strategy using chiral peptides to aid recovery in damaged tissues.
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Background: Currently, oblique placement of long implants or the use of short implants to circumvent the maxillary sinus area and provide support for fixed prostheses are viable alternatives. The purpose of this study was to compare these two treatment concepts and ascertain which one exhibits superior biomechanical characteristics.

Methods: Two different treatment concept models were constructed.

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Bacterial has become a common pathogen of humans owing to their drug-resistant effects and evasion of the host immune system, with their ability to form biofilm and induce severe infections, a condition which has become a primary public health concern globally. Herein, we report on CuO@AgO/ZnO NPs antibacterial activity enhanced by near-infrared (NIR) light which was effective in the elimination of and the . The CuO@AgO/ZnO NPs under NIR significantly eradicated and its biofilm and , and subsequently exhibited such phenomenon , eliminating bacteria and healing wound.

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To effectively treat diabetic wounds, the development of versatile medical dressings that can long-term regulate blood glucose and highly effective anti-oxidative stress, antibacterial and anti-inflammatory are critical. Here, an all-in-one CO gas-therapy-based versatile hydrogel dressing (ICOQF) was developed via the dynamic Schiff base reaction between the amino groups on quaternized chitosan (QCS) and the aldehyde groups on benzaldehyde-terminated F108 (F108-CHO) micelles. CORM-401 (an oxidant-sensitive CO-releasing molecules) was encapsulated in the hydrophobic core of F108-CHO micelles and insulin was loaded in the three-dimensional network structure of ICOQF.

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Chiral semiconductor nanostructures have received enormous attention due to their emerging circularly polarized luminescence (CPL) properties. However, compared with well-studied photoluminescence (PL), the reported CPL is much weaker and more challenging to be modulated. Herein, we describe a new approach for acquiring the intense and tunable CPL from inorganic chiral photonic crystals (CPCs) doped with semiconductor quantum dots (QDs).

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Development of versatile medical dressing with good immediate and long-lasting antibacterial, hygroscopic and moisturizing abilities is of great significance for management of chronic wounds. Cotton gauze (CG) can protect wounds and promote scabbing, but can cause wound dehydration and loss of biologically active substances, thereby greatly delays wound healing. Herein, a bi-functional CG dressing (CPCG) was developed by chemically grafting polyhexamethylene guanidine (PHMG) and physically adsorbing chitosan (CS) onto the CG surface.

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