Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors.

Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately needed. Monoamine oxidase A (MAO-A)-activated therapeutic and diagnostic compounds provide great selectivity because MAO-A can be employed as a biomarker for associated Tumors. In order to screen photosensitizers with photodynamic therapeutic potential, we have created a range of near-infrared fluorescent molecules in this work by combining dihydroxanthene parent with various heterocyclic fluorescent dyes.

Monoamine oxidase B activatable red fluorescence probe for bioimaging in cells and zebrafish.

A real-time and specific for the detection of Monoamine Oxidase B (MAO-B) to investigate the MAO-B-relevant disease development and treatment process is urgently desirable. Here, we utilized MAO-B to catalyze the conversion of propylamino groups to aldehyde groups, which was then quickly followed by a β-elimination process to produce fluorescent probes (FNJP) that may be used to detect MAO-B in vitro and in vivo. The FNJP probe possesses unique properties, including favorable reactivity (K = 10.

Multi-strand Fibers with Hierarchical Helical Structures Driven by Water or Moisture for Soft Actuators.

Smart actuators that combine excellent mechanical properties and responsive actuating performance like biological muscles have attracted considerable attention. In this study, a water/humidity responsive actuator, consisting of multi-strand carboxyl methyl cellulose (CMC) fibers with helical structures, was prepared using wet-spinning and twisting methods. The results showed that owing to the multi-strand structure, the actuator consisted of one-, two-, three-, and four-strand helical fibers, thus achieving a combination of high strength (∼27 MPa), high toughness (>10.

[Determination of 105 pesticide residues in vegetables by QuEChERS-liquid chromatography-tandem mass spectrometry].

After optimization of the QuEChERS pretreatment method, combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology, a multi-residue determination method was established for 105 typical insecticides, bactericides, herbicides, and plant growth regulators in vegetables. The target compounds were extracted by acetonitrile, purified with 150 mg primary secondary amine (PSA), 150 mg EC-C18, and 30 mg graphitized carbon black (GCB) adsorbents. The standard curves of 105 target compounds were linear in the concentration range of 0.