The interplay of global climate change and anthropogenic activities has significantly affected the carbon cycle in coastal ocean environments. Consequently, further investigation into the carbonate system, carbon source and sink processes, and acidification mechanisms is essential. This study examined the surface carbonate system offshore of Qingdao, utilizing data from nine spring cruises in 2011-2019.
View Article and Find Full Text PDFThe organic carbon (OC) cycle at the land-ocean interface is an important component of the global carbon budget, yet the processes that control the transfer, transformation, and burial of OC in these regions remain poorly understood. In this work, we examined sedimentary OC (SOC) in short core sediments, dissolved inorganic carbon (DIC), dissolved organic carbon (DOC), and chromophoric dissolved organic matter (CDOM), as well as other solutes in sediment porewaters of the Changjiang Estuary and adjacent East China Sea (ECS) shelf. The main goal of this work is to investigate the variation of the sources and composition of different forms of carbon in estuarine sediments associated with different sedimentary regimes, to further understand the role of sediment porewater in carbon sequestration at the land-ocean interface.
View Article and Find Full Text PDFBackground: Obstructive sleep apnea syndrome (OSAS) combined with heart failure (HF) has become a serious disease that threatens human health. Therapeutic interventions targeting OSAS have been shown to improve outcomes in patients with HF, so the identification of severe OSAS in HF is critical. Carbohydrate antigen 125 (CA125) is associated with inflammation and volume overload.
View Article and Find Full Text PDFObjective: Inflammation and immune cells are closely intertwined mechanisms that contribute to the progression of heart failure (HF). Nonetheless, there is a paucity of information regarding the distinct features of dysregulated immune cells and efficient diagnostic biomarkers linked with HF. This study aims to explore diagnostic biomarkers related to immune cells in HF to gain new insights into the underlying molecular mechanisms of HF and to provide novel perspectives for the detection and treatment of HF.
View Article and Find Full Text PDFAims: To develop and validate a risk prediction model for Chinese patients with type 2 diabetes with the recurrence of diabetic foot ulcers (DFUs) based on a systematic review and meta-analysis.
Methods: A prospective analysis was performed with 1333 participants and followed up for 60 months. Three models were analysed using a derived cohort.
Background: Bile acids can regulate liver disease progression by affecting the functions of gut microbiota and immune cells. As the most potent natural agonist of G-protein coupled bile acid receptor 5 (TGR5) (expressed in macrophages, HSCs, and monocytes), lithocholic acid (LCA) has multiple functions, such as inhibiting inflammation and regulating metabolism. Therefore, this study aims to investigate the effects of LCA on immune cells and HSCs in liver fibrosis.
View Article and Find Full Text PDF: The pathogenesis of metabolic associated fatty liver disease (MAFLD) is complex. Lipid metabolic disorder, chronic inflammation, and oxidative stress are the core events for MAFLD. Dietary intervention is an important treatment strategy for preventing the onset and progression of MAFLD.
View Article and Find Full Text PDFComput Intell Neurosci
April 2022
Image coloring is a time-consuming and laborious work. For a work, color collocation is an important factor to determine its quality. Therefore, automatic image coloring is a topic with great research significance and application value.
View Article and Find Full Text PDFObjectives: To develop and validate a model for predicting the risk of early diabetic foot ulcer (DFU) based on systematic review and meta-analysis.
Methods: Data were analyzed from the risk factors of DFU with their corresponding risk ratio (RR) by meta-analysis. The DFU prediction model included statistically significant risk factors from the meta-analysis, all of which were scored by its weightings, and the prediction model was externally validated using a validation cohort from China.
Background And Aims: Patients with decompensated HBV-related liver cirrhosis (HBV D-LC) showed compromised immune responses, which manifested as a proneness to develop infections and hyporesponsiveness to vaccines, resulting in accelerated disease progression. The alterations in T cell-dependent B cell responses in this pathophysiological process were not well understood. This study aimed to investigate T cell-dependent B cell responses in this process and discuss the mechanism from the perspective of metabolism.
View Article and Find Full Text PDFWorld J Gastroenterol
June 2021
Background: Previous studies found that ambient air pollution was associated with a higher prevalence of depressive symptoms. However, the longitudinal associations between household solid fuel use, which is the main source of household air pollution, and depressive symptoms remain unclear. This cohort study aimed to explore the associations between household solid fuel use and incidence of depressive symptoms in China.
View Article and Find Full Text PDFStudies of marine benthic archaeal communities are updating our view of their taxonomic composition and metabolic versatility. However, large knowledge gaps remain with regard to community assembly processes and inter taxa associations. Here, using 16S rRNA gene amplicon sequencing and qPCR, we investigated the spatiotemporal dynamics, assembly processes, and co-occurrence relationships of the archaeal community in 58 surface sediment samples collected in both summer and winter from across ~1500 km of the eastern Chinese marginal seas.
View Article and Find Full Text PDFBackground: Spontaneous peritonitis is one of the most common infectious complications in cirrhotic patients with ascites. Spontaneous fungal peritonitis (SFP) is a type of spontaneous peritonitis that is a less recognized but devastating complication in end-stage cirrhosis. Although high mortality was previously noted, scant data are available to fully define the factors responsible for the occurrence of SFP and its mortality.
View Article and Find Full Text PDFThe aims of the present study were to investigate the effects of angiotensin receptor neprilysin inhibitors (ARNi) on the susceptibility of ventricular arrhythmias (VAs) in rats with myocardial infarction (MI) and to explore the related mechanisms.A total of 32 adult male Sprague-Dawley rats were divided into 3 groups: a control group, MI group, and MI+ARNi group. MI was generated by ligation of the left anterior descending coronary artery.
View Article and Find Full Text PDFSingle nuclear polymorphism (SNP) of programmed cell death 1 (PD-1) was reported associated with hepatitis B virus (HBV) infection, but the SNP sites studied were limited. Whether the combination of 2 or more SNP sites could better represent the relationship between PD-1 SNP and HBV infection was not studied.Eight hundred ninety-eight HBV-infected patients (222 asymptomatic carriers [AsC], 276 chronic hepatitis B, 105 acute-on-chronic liver failure, and 295 liver cirrhosis) and 364 health controls of South China were enrolled in this study.
View Article and Find Full Text PDFBackground: Myocardial remodeling is the key step in the development of ischemic cardiomyopathy. We aimed to compare effects of renal denervation (RDN) with those of angiotensin receptor neprilysin inhibitors (ARNi) on cardiac remodeling after myocardial infarction (MI), and explore underlying mechanism.
Methods: Sprague-Dawley rats (n = 40; male) were subjected to ligation of left anterior descending coronary artery to induce MI; six rats served as controls.
Hypertrophic cardiomyopathy (HCM) is reported to be the most common genetic heart disease. To identify key module and candidate biomarkers correlated with clinical prognosis of patients with HCM, we carried out this study with co-expression analysis. To construct a co-expression network of hub genes correlated with HCM, the Weighted Gene Co-expression Network Analysis (WGCNA) was performed.
View Article and Find Full Text PDFBackground: Cirrhosis always goes with profound immunity compromise, and makes those patients easily be the target of pneumonia. Cirrhotic patients with pneumonia have a dramatically increased mortality. To recognize the risk factors of mortality and to optimize stratification are critical for improving survival rate.
View Article and Find Full Text PDFAmmonia-oxidizing archaea (AOA) and bacteria (AOB) vary in their contribution to nitrification in different environments. The eastern China marginal seas (ECMS) are featured by complex river runoffs and ocean currents, forming different sediment patches. Here, via quantitative PCR and clone library analysis of the amoA genes, we showed that AOB were more abundant than AOA in ECMS sediments.
View Article and Find Full Text PDFSolar ultraviolet (UV) radiation is a major cause of erythema and skin cancer in humans and the face is one of the highest risk sites. Biologically effective UV irradiation (UVBE) is wavelength-dependent, and risk assessment has been demonstrated based on the value of the received UV radiation. Therefore, this study measured the face skin exposure to UV spectral irradiance using a spectroradiometer and a head manikin, which were weighted by action spectra to calculate the UVBE that causes erythema (UVBEery), non-melanoma (UVBEnon-mel), human squamous cell cancer (UVBEh-SCC), and DNA damage (UVBEDNA-d).
View Article and Find Full Text PDFHuman outdoor activities are randomly orientated at different angles to the sun. To quantify the ocular UV and biologically effective UV (UVBE; i.e.
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